5-(4-(3-hydroxy-6-oxo-6H-xanthen-9-yl)phenoxy)pentanoic acid | 1429666-35-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 5-(4-(3-hydroxy-6-oxo-6H-xanthen-9-yl)phenoxy)pentanoic acid
• 英文别名: 5-[4-(3-hydroxy-6-oxoxanthen-9-yl)phenoxy]pentanoic acid
• CAS: 1429666-35-2
• 化学式: C₂₄H₂₀O₆
• 分子量: 404.419
• InChiKey: VIVXXGLBRCLOPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  5-(4-formylphenoxy)pentanoic acid 、 间苯二酚 、 1-ethyl-2,2,4-trimethyl-1,2-dihydroquinolin-7-ol 、 4-甲酰苯氧基乙酸 以 甲醇 为溶剂， 生成 5-(4-(3-hydroxy-6-oxo-6H-xanthen-9-yl)phenoxy)pentanoic acid
  参考文献：
  名称：

  Fluorescent dyes

  摘要：

  提供了多种化合物，其化学式为上述化合物。同时提供了包含上述化合物的荧光染料。此外，还提供了荧光能量转移系统，其中包括上述荧光染料和第二种染料，第二种染料能够与荧光染料进行能量转移。还提供了用于标记靶分子的试剂盒，其中包括上述荧光染料和其他有用于标记靶分子的试剂。此外，还提供了用上述荧光染料标记的靶分子。还提供了使用上述荧光染料标记靶分子的方法。

  公开号：

  US09416153B2

文献信息

• FLUORESCENT DYES
  申请人：LI ZAIGUO

  公开号：US20130089853A1

  公开（公告）日：2013-04-11

  Provided are various compounds comprising the formula Also provided are fluorescent dyes comprising the above compound. Additionally, a fluorescence energy transfer system is provided that comprises the above-described fluorescent dye and a second dye, wherein the second dye is capable of energy transfer with the fluorescent dye. Further provided is a kit for labeling a target molecule, where the kit comprises the above-described fluorescent dye with additional reagents useful for labeling the target molecule. Additionally provided is a target molecule labeled with the above-described fluorescent dye. A method of labeling a target molecule is also provided. The method comprises contacting reactive group Z of the above-described fluorescent dye with the target molecule such that reactive group Z reacts with the target molecule to form a covalent bond between reactive group Z and the target molecule. Also, another method of labeling a target molecule is provided. The method comprises contacting the above-described fluorescent dye, which further comprises a member of a binding pair, with the target molecule, where the target molecule comprises a second member of the binding pair.

  提供了包含以下化合物的各种化合物。还提供了包含上述化合物的荧光染料。此外，提供了一种荧光能量转移系统，其中包括上述描述的荧光染料和第二染料，其中第二染料能够与荧光染料进行能量转移。还提供了一个用于标记目标分子的试剂盒，其中试剂盒包括上述描述的荧光染料以及用于标记目标分子的其他试剂。此外，还提供了一个用上述荧光染料标记的目标分子。还提供了一种标记目标分子的方法。该方法包括将上述荧光染料的反应基团Z与目标分子接触，使得反应基团Z与目标分子发生反应，形成反应基团Z与目标分子之间的共价键。另外，还提供了另一种标记目标分子的方法。该方法包括将上述荧光染料与结合对的成员之一进一步结合，然后与目标分子接触，其中目标分子包含结合对的第二成员。
• Fluorescent dyes and methods of use thereof
  申请人：ENZO LIFE SCIENCES, INC.

  公开号：US10106573B2

  公开（公告）日：2018-10-23

  Provided are methods for labeling target molecules, such as nucleic acids, with fluorescent dye compounds having the formula One method embodiment includes contacting reactive group Z of the fluorescent dye compound with the target molecule such that reactive group Z reacts with the target molecule to form a covalent bond between the group and the target molecule. Another method embodiment includes contacting a fluorescent dye compound that further includes a first member of a binding pair, with a target molecule that includes a second member of the binding pair. Also provided are target molecules labeled with the fluorescent dye compounds.

  本发明提供了用荧光染料化合物标记目标分子（如核酸）的方法，荧光染料化合物的化学式为 一种方法的实施方案包括将荧光染料化合物的活性基团 Z 与目标分子接触，使活性基团 Z 与目标分子反应，在该基团与目标分子之间形成共价键。另一个方法实施例包括将进一步包括结合对第一成员的荧光染料化合物与包括结合对第二成员的靶分子接触。还提供了用荧光染料化合物标记的靶分子。
• FLUORESCENT DYES AND METHODS OF USE THEREOF
  申请人：ENZO LIFE SCIENCES, INC. C/O ENZO BIOCHEM, INC.

  公开号：US20160311846A1

  公开（公告）日：2016-10-27

  Provided are methods for labeling target molecules, such as nucleic acids, with fluorescent dye compounds having the formula One method embodiment includes contacting reactive group Z of the fluorescent dye compound with the target molecule such that reactive group Z reacts with the target molecule to form a covalent bond between the group and the target molecule. Another method embodiment includes contacting a fluorescent dye compound that further includes a first member of a binding pair, with a target molecule that includes a second member of the binding pair. Also provided are target molecules labeled with the fluorescent dye compounds.
• US9416153B2
  申请人：——

  公开号：US9416153B2

  公开（公告）日：2016-08-16
• [EN] FLUORESCENT DYES<br/>[FR] COLORANTS FLUORESCENTS
  申请人：ENZO LIFE SCIENCES INC

  公开号：WO2013055647A1

  公开（公告）日：2013-04-18

  Provided are various compounds comprising the formula Also provided are fluorescent dyes comprising the above compound. Additionally, a fluorescence energy transfer system is provided that comprises the above-described fluorescent dye and a second dye, wherein the second dye is capable of energy transfer with the fluorescent dye. Further provided is a kit for labeling a target molecule, where the kit comprises the above-described fluorescent dye with additional reagents useful for labeling the target molecule. Additionally provided is a target molecule labeled with the above-described fluorescent dye. Methods of labeling a target molecule with the above-described fluorescent dye are also provided.