2-methyl-6-nitro-4-oxo-4H-quinazoline-3-carboxylamide | 1226498-79-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-methyl-6-nitro-4-oxo-4H-quinazoline-3-carboxylamide
• 英文别名: 2-Methyl-6-nitro-4-oxoquinazoline-3-carboxamide
• CAS: 1226498-79-8
• 化学式: C₁₀H₈N₄O₄
• 分子量: 248.198
• InChiKey: SJEBLQKZLGMHSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  122
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-甲基-6-硝基-4H-苯并[d][1,3]恶嗪-4-酮 、 尿素 以 乙醇 为溶剂， 反应 3.0h， 以65%的产率得到2-methyl-6-nitro-4-oxo-4H-quinazoline-3-carboxylamide
  参考文献：
  名称：

  Investigating the anti-proliferative activity of styrylazanaphthalenes and azanaphthalenediones

  摘要：

  A group of styrylazanaphthalenes and azanaphthalenediones were synthesized and tested for their anti-proliferative activity. Most of the compounds were obtained with the use of microwave-assisted synthesis. The lipophilicity of the compounds was measured by RP-HPLC and their anti-proliferative activity was assayed against the human SK-N-MC neuroepithelioma and HCT116 human colon carcinoma cell lines. Active compounds were also tested in clonogenity and comet assays. Several quinazolinone and styrylquinazoline analogues were found to have markedly greater anti-proliferative activity than desferoxamine and cis-platin. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.02.025

文献信息

• Investigating the anti-proliferative activity of styrylazanaphthalenes and azanaphthalenediones
  作者：Anna Mrozek-Wilczkiewicz、Danuta S. Kalinowski、Robert Musiol、Jacek Finster、Agnieszka Szurko、Katarzyna Serafin、Magdalena Knas、Sishir K. Kamalapuram、Zaklina Kovacevic、Josef Jampilek、Alicja Ratuszna、Joanna Rzeszowska-Wolny、Des R. Richardson、Jaroslaw Polanski

  DOI：10.1016/j.bmc.2010.02.025

  日期：2010.4

  A group of styrylazanaphthalenes and azanaphthalenediones were synthesized and tested for their anti-proliferative activity. Most of the compounds were obtained with the use of microwave-assisted synthesis. The lipophilicity of the compounds was measured by RP-HPLC and their anti-proliferative activity was assayed against the human SK-N-MC neuroepithelioma and HCT116 human colon carcinoma cell lines. Active compounds were also tested in clonogenity and comet assays. Several quinazolinone and styrylquinazoline analogues were found to have markedly greater anti-proliferative activity than desferoxamine and cis-platin. (C) 2010 Elsevier Ltd. All rights reserved.