4-[(4-cyanophenyl)-(1,2,4-triazol-1-yl)methyl]benzonitrile;(7R,8R,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol | 1219980-23-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 4-[(4-cyanophenyl)-(1,2,4-triazol-1-yl)methyl]benzonitrile;(7R,8R,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
• CAS: 1219980-23-0
• 化学式: C49H58F5N5O3S
• 分子量: 892.1
• InChiKey: FSMCBXYOQCPZBH-IMXUXLGRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.34
• 重原子数：
  63
• 可旋转键数：
  17
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  155
• 氢给体数：
  2
• 氢受体数：
  13

文献信息

• OLIGONUCLEOTIDE PROBES AND USES THEREOF
  申请人：Caris Science, Inc.

  公开号：EP3828272A1

  公开（公告）日：2021-06-02

  Methods and compositions are provided to identify oligonucleotides that bind targets of interest. The targets include tissues, cells, circulating biomarkers such as microvesicles, including those derived from various diseases. The oligonucleotides can be used in diagnostic and therapeutic applications.

  提供的方法和组合物能识别与感兴趣的靶标结合的寡核苷酸。这些靶标包括组织、细胞、循环生物标志物，如微囊泡，包括来自各种疾病的微囊泡。寡核苷酸可用于诊断和治疗。
• ANTI-CANCER THERAPY WITH AN EXTRACT OF SCUTELLARIA BARBATA
  申请人：Cohen Isaac

  公开号：US20090130101A1

  公开（公告）日：2009-05-21

  Methods of treating cancer with a combination of an extract of Scutellaria barbata D. Don and at least one additional anticancer chemotherapeutic agent are provided. Also provided are kits comprising an extract of Scutellaria barbata D. Don and at least one additional anticancer chemotherapeutic agent.
• PROCESS OF MAKING PURIFIED EXTRACT OF SCUTELLARIA BARBATA D. DON
  申请人：Cohen Isaac

  公开号：US20090130237A1

  公开（公告）日：2009-05-21

  An extract of Scutellaria barbata D. Don is effective in the arrest of cancer cell growth in the G1 phase, the induction of apoptosis in cancer cells and the shrinking of solid cancers. The extract may be prepared as a pharmaceutical composition for administration to mammals for the treatment of solid cancers, such as epithelial cancers. Such epithelial cancers include breast cancer and ovarian cancers. The extract is obtained from Scutellaria barbata D. Don by contacting aerial portions of a plant from the species Scutellaria barbata D. Don with an aqueous or alcoholic solvent.
• SCUTELLARIA BARBATA EXTRACT FOR THE TREATMENT OF CANCER
  申请人：Cohen Isaac

  公开号：US20100143511A1

  公开（公告）日：2010-06-10

  An extract of Scutellaria barbata D. Don is effective in the arrest of cancer cell growth in the G1 phase, the induction of apoptosis in cancer cells and the shrinking of solid cancers. The extract may be prepared as a pharmaceutical composition for administration to mammals for the treatment of solid cancers, such as epithelial cancers. Such epithelial cancers include breast cancer and ovarian cancers. The extract is obtained from Scutellaria barbata D. Don by contacting aerial portions of a plant from the species Scutellaria barbata D. Don with an aqueous or alcoholic solvent.
• US8197868B2
  申请人：——

  公开号：US8197868B2

  公开（公告）日：2012-06-12