(3-chloro-4-fluoro-phenyl)-(1H-imidazol-2-ylmethyl)-amine | 1020670-26-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (3-chloro-4-fluoro-phenyl)-(1H-imidazol-2-ylmethyl)-amine
• 英文别名: 3-chloro-4-fluoro-N-(1H-imidazol-2-ylmethyl)aniline
• CAS: 1020670-26-1
• 化学式: C₁₀H₉ClFN₃
• 分子量: 225.653
• InChiKey: IWHZOMVKJZIJDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  40.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• AMINOMETHYL-2-IMIDAZOLES
  申请人：Galley Guido

  公开号：US20080096906A1

  公开（公告）日：2008-04-24

  The present invention relates to compounds of formula I wherein R 1 is selected from the group consisting of hydrogen or lower alkyl; R 2 is hydrogen, lower alkyl, lower alkenyl, lower alkyl substituted by hydroxy, lower alkyl substituted by halogen, —(CH 2 ) x —S-lower alkyl, —(CH 2 ) x —O-lower alkyl, —(CH 2 ) x —NHC(O)O-lower alkyl, —(CH 2 ) x -aryl, and —(CH 2 ) x -heteroaryl; each R 3 is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, halogen, hydroxy, lower alkyl substituted by halogen, —O—(CH 2 ) m -aryl, —O—(CH 2 ) m -heteroaryl, —(CR 2 ) m -aryl, and —(CR 2 ) m -heteroaryl; each R is selected from the group consisting of hydrogen, lower alkyl and hydroxy; Ar is selected from the group consisting of phenyl, pyrimidin-2-yl, pyrimidin-4-yl and pyridin-3-yl; n is 0, 1 or 2; x is 0, 1, 2 or 3; m is 0 or 1; and to their pharmaceutically active salts.

  本发明涉及以下式I的化合物 其中 R1选择自羟基或较低烷基; R2为氢、较低烷基、较低烯基、被羟基取代的较低烷基、被卤素取代的较低烷基、—(CH2)x—S-较低烷基、—( )x—O-较低烷基、—( )x—NHC(O)O-较低烷基、—( )x-芳基和—( )x-杂环基中的一种; 每个R3选择自氢、较低烷基、较低烷氧基、卤素、羟基、被卤素取代的较低烷基、—O—( )m-芳基、—O—( )m-杂环基、—(CR2)m-芳基和—(CR2)m-杂环基中的一种; 每个R选择自氢、较低烷基和羟基; Ar选择自苯基、嘧啶-2-基、嘧啶-4-基和吡啶-3-基; n为0、1或2; x为0、1、2或3; m为0或1; 以及其药用活性盐。
• ANTIBACTERIAL 4,5-SUBSTITUTED AMINOGLYCOSIDE ANALOGS HAVING MULTIPLE SUBSTITUENTS
  申请人：Isis Pharmaceuticals, Inc.

  公开号：EP1957507A2

  公开（公告）日：2008-08-20
• AMINOMETHYL-2-IMIDAZOLES WITH AFFINITY WITH THE TRACE AMINE ASSOCIATED RECEPTORS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2076496A1

  公开（公告）日：2009-07-08
• TRACE AMINE ASSOCIATED RECEPTOR 1 AGONISTS AND PARTIAL AGONISTS FOR PAIN TREATMENT
  申请人：Purdue Pharma LP

  公开号：EP3463359A1

  公开（公告）日：2019-04-10
• [EN] ANTIBACTERIAL 4,5-SUBSTITUTED AMINOGLYCOSIDE ANALOGS HAVING MULTIPLE SUBSTITUENTS<br/>[FR] ANALOGUES D'AMINOGLYCOSIDE 4,5-SUBSTITUÉS ANTIBACTÉRIENS COMPORTANT PLUSIEURS SUBSTITUANTS
  申请人：ISIS PHARMACEUTICALS INC

  公开号：WO2007064954A2

  公开（公告）日：2007-06-07

  [EN] The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.
  [FR] L'invention concerne des analogues de composés aminoglycoside, ainsi que leur préparation et leur utilisation en tant qu'agents destinés à prévenir ou traiter une infection microbienne.