3-{2-[4-(2-azepan-1-yl-ethoxy)-phenylamino]-quinazolin-6-yl}-4-chloro-phenol | 1234096-42-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-{2-[4-(2-azepan-1-yl-ethoxy)-phenylamino]-quinazolin-6-yl}-4-chloro-phenol
• 英文别名: 3-[2-[4-[2-(Azepan-1-yl)ethoxy]anilino]quinazolin-6-yl]-4-chlorophenol
• CAS: 1234096-42-4
• 化学式: C₂₈H₂₉ClN₄O₂
• 分子量: 489.017
• InChiKey: BERSKKCARFLVRV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  70.5
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• SUBSTITUTED QUINAZOLINE COMPOUNDS
  申请人：Leriche Caroline

  公开号：US20120004210A1

  公开（公告）日：2012-01-05

  The invention is directed to certain novel compounds, methods for producing them and methods for treating or ameliorating a kinase-mediated disorder. More particularly, this invention is directed to substituted quinazoline compounds useful as selective kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase-mediated disorder, In particular, the methods relate to treating or ameliorating a kinase-mediated disorder including cardiovascular diseases, diabetes, diabetes-associated disorders, inflammatory diseases, immunological disorders, cancer and diseases of the eye such as retinopathies or macular degeneration or other vitreoretinal diseases, and the like.
• US8389530B2
  申请人：——

  公开号：US8389530B2

  公开（公告）日：2013-03-05