Nolomirole, (S)- | 146085-50-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: Nolomirole, (S)-
• 英文别名: [(6S)-6-(methylamino)-1-(2-methylpropanoyloxy)-5,6,7,8-tetrahydronaphthalen-2-yl] 2-methylpropanoate
• CAS: 146085-50-9
• 化学式: C₁₉H₂₇NO₄
• 分子量: 333.4
• InChiKey: OMMYLOLVPCCZQZ-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Optically active2-aminotetralin derivatives, the processes for the preparation thereof and the therapeutical use of pharmaceutical compositions containing them
  申请人：——

  公开号：US20040102652A1

  公开（公告）日：2004-05-27

  The use of the optically active forms of 5,6-dihydroxy-2-methylaminotetralin and acyl esters thereof as medicaments for cardiovascular diseases a process for the preparation thereof and their use in pharmaceutical compositions.

  将5,6-二羟基-2-甲基氨基四氢萘及其酰基酯的光学活性形式用作心血管疾病药物的使用，以及制备这些药物的过程和它们在药物组合物中的使用。
• Methods, compositions, and kits for the treatment of ophthalmic disorders
  申请人：CombinatoRx, Inc.

  公开号：EP2218442A1

  公开（公告）日：2010-08-18

  The invention features methods, compositions and kits comprising a corticosteroid and a non-steroidal immunophilin-dependent immunosuppressant for treating an ophthalmic disorder in a patient, wherein at least one of said corticosteroid and said non-steroidal immunophilin-dependent immunosuppressant is present at a low concentration, in particular wherein said corticosteroid is prednisolone acetate and said non-steroidal immunophilin-dependent immunosuppressant is cyclosporine A.

  本发明的特征是包含皮质类固醇和非类固醇免疫嗜血素依赖性免疫抑制剂的方法、组合物和试剂盒，用于治疗患者的眼科疾病、其中，所述皮质类固醇和所述非类固醇免疫嗜血素依赖性免疫抑制剂中至少有一种以低浓度存在，特别是所述皮质类固醇为醋酸泼尼松龙，所述非类固醇免疫嗜血素依赖性免疫抑制剂为环孢素 A。
• 2-AMINOTETRALIN DERIVATIVES FOR THE THERAPY OF GLAUCOMA
  申请人：CHIESI FARMACEUTICI S.p.A.

  公开号：EP1200079A2

  公开（公告）日：2002-05-02
• METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF MEDICAL CONDITIONS
  申请人：CombinatoRx, Incorporated

  公开号：EP1956906A2

  公开（公告）日：2008-08-20
• Methods, compositions, and kits for the treatment of medical conditions
  申请人：Chappell W. Todd

  公开号：US20070225217A1

  公开（公告）日：2007-09-27

  The invention features methods, compositions, and kits for treating an immunoinflammatory disorder, an ophthalmic disorder, a musculoskeletal disorder or pain associated therewith, a periodontal disease, or a disease or condition associated with an increased serum CRP level.