(R)-α-methyl-para-fluorophenylalanine

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: (R)-α-methyl-para-fluorophenylalanine
• 英文别名: (2R)-2-azaniumyl-3-(4-fluorophenyl)-2-methylpropanoate
• 化学式: C₁₀H₁₂FNO₂
• 分子量: 197.209
• InChiKey: BBRMBENCQBOTHY-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-氟溴苄 在 (R,R)-3,4,5-trifluorophenyl-NAS bromide cesium hydroxide 作用下， 以 甲苯 为溶剂， 生成 (R)-α-methyl-para-fluorophenylalanine
  参考文献：
  名称：

  Wouters, L.; Lemaire, C.; Plenevaux, A., Journal of labelled compounds and radiopharmaceuticals, 2003, vol. 46, p. S206 - S206

  摘要：

  DOI：

文献信息

• Chiral salen-metal complexes as novel catalysts for asymmetric phase transfer alkylations
  作者：Yuri N. Belokon、Michael North、Vadim S. Kublitski、Nikolai S. Ikonnikov、Pavel E. Krasik、Viktor I. Maleev

  DOI：10.1016/s0040-4039(99)01214-9

  日期：1999.8

  salen-metal complexes have been tested as catalysts for the C-alkylation of aldimine Schiff's bases of alanine esters with alkyl bromides under phase-transfer conditions (solid sodium hydroxide, toluene, ambient temperature, 1–10% of the catalyst). The best catalyst, which was derived from a Cu(II) complex of (1R,2R or 1S,2S)-[N,N′-bis(2′-hydroxybenzylidene)]-1,2-diaminocyclohexane, gave α-methyl-α-amino

  在相转移条件下（固体氢氧化钠，甲苯，环境温度，催化剂的1-10％），手性的Salen-金属络合物已作为催化剂用于醛亚胺Schiff丙氨酸酯与烷基溴的C-烷基化反应中。最好的催化剂是由（1 R，2 R或1 S，2 S）-[ N，N'-双（2'-羟基亚苄基）]-1,2-二氨基环己烷的Cu（II）络合物衍生的，得到对映体过量70-96％的α-甲基-α-氨基酸。
• Methods of using macrocyclic modulators of the ghrelin receptor
  申请人：Fraser L. Graeme

  公开号：US20070021331A1

  公开（公告）日：2007-01-25

  The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders.
• MODIFIED CLEAVASES, USES THEREOF AND RELATED KITS
  申请人：Encodia, Inc.

  公开号：US20210214701A1

  公开（公告）日：2021-07-15

  Provided herein are modified cleavases for removing amino acids from peptides, polypeptides, and proteins. Also provided are methods of using the modified cleavases for treating polypeptides, and kits comprising the modified cleavase. In some embodiments, the methods and the kits also include other components for macromolecule sequencing and/or analysis.
• US5554753A
  申请人：——

  公开号：US5554753A

  公开（公告）日：1996-09-10
• US7491695B2
  申请人：——

  公开号：US7491695B2

  公开（公告）日：2009-02-17