p-Dimethylamino-thioacetanilid | 38750-64-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: p-Dimethylamino-thioacetanilid
• 英文别名: 4-Dimethylamino-thioacetanilid；N-[4-(dimethylamino)phenyl]ethanethioamide
• CAS: 38750-64-0
• 化学式: C₁₀H₁₄N₂S
• 分子量: 194.301
• InChiKey: NESGFBFTNLKZNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  47.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• PYRAZOLOPYRIDINES AND ANALOGS THEREOF
  申请人：Hays David S.

  公开号：US20090318435A1

  公开（公告）日：2009-12-24

  Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, and 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

  本文介绍了吡唑吡啶-4-胺，吡唑喹啉-4-胺，吡唑萘啉-4-胺和6,7,8,9-四氢吡唑喹啉-4-胺，含有这些化合物的药物组合物，中间体，制备方法以及这些化合物作为免疫调节剂的用途，用于诱导或抑制动物细胞因子生物合成，以及用于治疗包括病毒和肿瘤疾病在内的疾病。
• 2-Amino 1H-Imidazo Ring Systems and Methods
  申请人：Kshirsagar Tushar A.

  公开号：US20090023720A1

  公开（公告）日：2009-01-22

  1H-Imidazo ring systems (e.g., imidazopyridines, imidazoquinolines, imidazonaphthyridines, 6,7,8,9-tetrahydro imidazoquinolines and imidazonaphthyridines) with an amino substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

  本发明揭示了在2-位置具有氨基取代基的咪唑环系统（例如咪唑吡啶，咪唑喹啉，咪唑萘啉，6,7,8,9-四氢咪唑喹啉和咪唑萘啉），含有这些化合物的制药组合物，制备这些化合物的方法，中间体以及这些化合物作为免疫调节剂的用途，用于调节动物细胞因子生物合成以及治疗包括病毒和肿瘤性疾病在内的疾病的方法。
• Piperazine, [1,4]Diazepane, [1,4]Diazocane, and [1,5]Diazocane fused imidazo ring compounds
  申请人：Kshirsagar A. Tushar

  公开号：US20070167476A1

  公开（公告）日：2007-07-19

  Piperazine, [1,4]diazepane, [1,4]diazocane, and [1,5]diazocane fused imidazo ring compounds (i.e., imidazoquinolines, tetrahydroimidazoquinolines, imidazonaphthyridines, tetrahydroimidazonaphthyridines, and imidazopyridines), pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

  本文介绍了哌嗪、[1,4]二氮杂辛烷、[1,4]二氮杂庚烷和[1,5]二氮杂庚烷融合的咪唑环化合物（即咪唑喹啉、四氢咪唑喹啉、咪唑萘啉、四氢咪唑萘啉和咪唑吡啶），以及含有这些化合物的制药组合物、中间体、制备方法和用于动物中诱导或抑制细胞因子生物合成以及治疗包括病毒和肿瘤疾病在内的疾病的方法。
• Pyrazolopyridines and Analogs Thereof
  申请人：Hays David S.

  公开号：US20090075980A1

  公开（公告）日：2009-03-19

  Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, and prodrugs thereof, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

  本文披露了吡唑吡啶-4-胺、吡唑喹啉-4-胺、吡唑萘啉-4-胺、6,7,8,9-四氢吡唑喹啉-4-胺及其前药、含有这些化合物的制药组合物、中间体、制备方法以及这些化合物作为免疫调节剂的使用方法，包括在动物中诱导或抑制细胞因子生物合成以及治疗病毒和肿瘤性疾病。
• US7544697B2
  申请人：——

  公开号：US7544697B2

  公开（公告）日：2009-06-09