6-Chloro-1,2,3,4-tetrahydro-[1]benzofuro[3,2-c]pyridine | 260273-72-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 6-Chloro-1,2,3,4-tetrahydro-[1]benzofuro[3,2-c]pyridine
• CAS: 260273-72-1
• 化学式: C₁₁H₁₀ClNO
• 分子量: 207.659
• InChiKey: VEQHLQKQAPWMPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  25.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(2-氯乙基)-2-甲基吡啶并[1,2-a]嘧啶-4-酮 、 6-Chloro-1,2,3,4-tetrahydro-[1]benzofuro[3,2-c]pyridine 在 sodium carbonate 作用下， 以 various solvent(s) 为溶剂， 生成 3-[2-(6-chloro-3,4-dihydro-1H-[1]benzofuro[3,2-c]pyridin-2-yl)ethyl]-2-methylpyrido[1,2-a]pyrimidin-4-one
  参考文献：
  名称：

  New 2-substituted 1,2,3,4-tetrahydrobenzofuro[3,2- c ]pyridine having highly active and potent central α 2 -antagonistic activity as potential antidepressants

  摘要：

  The synthesis and biological activity of a series of benzofuro[3,2-c]pyridines and a benzothieno[3,2-c]pyridine are described. These compounds exhibit high affinity for the alpha(2)-adrenoceptor, with high selectivity versus the alpha(1)-receptor. Compound 1 also shows potent in vivo central activity and has been selected for further biological and clinical evaluation. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00591-0
• 作为产物：
  描述：

  (7-Chloro-1-benzofuran-2-yl)methanol 在 镍 盐酸 、 氢气 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 生成 6-Chloro-1,2,3,4-tetrahydro-[1]benzofuro[3,2-c]pyridine
  参考文献：
  名称：

  New 2-substituted 1,2,3,4-tetrahydrobenzofuro[3,2- c ]pyridine having highly active and potent central α 2 -antagonistic activity as potential antidepressants

  摘要：

  The synthesis and biological activity of a series of benzofuro[3,2-c]pyridines and a benzothieno[3,2-c]pyridine are described. These compounds exhibit high affinity for the alpha(2)-adrenoceptor, with high selectivity versus the alpha(1)-receptor. Compound 1 also shows potent in vivo central activity and has been selected for further biological and clinical evaluation. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00591-0