3-chloro-6-methyl-2H-benzo[h]chromen-2-one | 1239990-59-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: 3-chloro-6-methyl-2H-benzo[h]chromen-2-one
• 英文别名: 3-Chloro-6-methylbenzo[h]chromen-2-one
• CAS: 1239990-59-0
• 化学式: C₁₄H₉ClO₂
• 分子量: 244.677
• InChiKey: HSXZIOKQRWMLDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-hydroxy-4-methyl-2-formylnaphthalene 、 氯乙酸乙酯 在 哌啶 作用下， 以 乙醇 为溶剂， 反应 0.5h， 以78%的产率得到3-chloro-6-methyl-2H-benzo[h]chromen-2-one
  参考文献：
  名称：

  Novel coumarin derivatives as potential antidyslipidemic agents

  摘要：

  A series of novel benzocoumarin derivatives were synthesized and evaluated for their in vivo antidyslipidemic and in vitro antioxidant activities. Among 11 compounds tested, 2 compounds showed potent antidyslipidemic activity and 3 compounds showed potent antioxidant activity. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.05.023

文献信息

• Novel coumarin derivatives as potential antidyslipidemic agents
  作者：Koneni V. Sashidhara、Abdhesh Kumar、Manoj Kumar、Ravi Sonkar、Gitika Bhatia、A.K. Khanna

  DOI：10.1016/j.bmcl.2010.05.023

  日期：2010.7

  A series of novel benzocoumarin derivatives were synthesized and evaluated for their in vivo antidyslipidemic and in vitro antioxidant activities. Among 11 compounds tested, 2 compounds showed potent antidyslipidemic activity and 3 compounds showed potent antioxidant activity. (C) 2010 Elsevier Ltd. All rights reserved.