(E)-2-(1,2-diphenylethenyl)-N,N-dimethyl-4-methylbenzamide | 1417034-33-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (E)-2-(1,2-diphenylethenyl)-N,N-dimethyl-4-methylbenzamide
• 英文别名: 2-[(E)-1,2-diphenylethenyl]-N,N,4-trimethylbenzamide
• CAS: 1417034-33-3
• 化学式: C₂₄H₂₃NO
• 分子量: 341.453
• InChiKey: VXTIPRDPNKCWLB-OQKWZONESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N,N-二甲基-4-甲基苯甲酰胺 、 二苯基乙炔 在 silver hexafluoroantimonate 、 [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 溶剂黄146 作用下， 以 1,4-二氧六环 为溶剂， 反应 5.0h， 以77%的产率得到(E)-2-(1,2-diphenylethenyl)-N,N-dimethyl-4-methylbenzamide
  参考文献：
  名称：

  Regioselective C–H Bond Cleavage/Alkyne Insertion under Ruthenium Catalysis

  摘要：

  The ruthenium-catalyzed coupling reactions of benzamides with alkynes in the presence of acetic acid as a promoter smoothly proceeded regio- and stereoselectively through a directed C-H bond cleavage to produce the corresponding ortho-alkenylated products. Phenylpyrazoles and related substrates also underwent a similar coupling to give dialkenylated products selectively. Several competitive experiments were performed to obtain mechanistic insight into both the mono- and dialkenylation reactions.

  DOI：

  10.1021/jo3025237

文献信息

• Regioselective C–H Bond Cleavage/Alkyne Insertion under Ruthenium Catalysis
  作者：Yuto Hashimoto、Koji Hirano、Tetsuya Satoh、Fumitoshi Kakiuchi、Masahiro Miura

  DOI：10.1021/jo3025237

  日期：2013.1.18

  The ruthenium-catalyzed coupling reactions of benzamides with alkynes in the presence of acetic acid as a promoter smoothly proceeded regio- and stereoselectively through a directed C-H bond cleavage to produce the corresponding ortho-alkenylated products. Phenylpyrazoles and related substrates also underwent a similar coupling to give dialkenylated products selectively. Several competitive experiments were performed to obtain mechanistic insight into both the mono- and dialkenylation reactions.