(4R)-2,2-diethyl-3,4-dihydrochromen-4-amine;(2S,3S)-2,3-dihydroxybutanedioic acid | 1257231-38-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: (4R)-2,2-diethyl-3,4-dihydrochromen-4-amine;(2S,3S)-2,3-dihydroxybutanedioic acid
• CAS: 1257231-38-1
• 化学式: C₄H₆O₆*C₁₃H₁₉NO
• 分子量: 355.388
• InChiKey: VAJGCUHTABOHFI-IMWLJMTPSA-N

反应信息

• 作为产物：
  描述：

  D-酒石酸 、 (4R)-4-azido-2,2-diethyl-3,4-dihydrochromene 在 palladium on activated carbon 、 氢气 作用下， 以 甲醇 、 异丙醇 为溶剂， 反应 3.0h， 生成 (4R)-2,2-diethyl-3,4-dihydrochromen-4-amine;(2S,3S)-2,3-dihydroxybutanedioic acid
  参考文献：
  名称：

  Efficient and general asymmetric syntheses of (R)-chroman-4-amine salts

  摘要：

  Starting from a variety of substituted chroman-4-ones, a highly enantioselective CBS reduction using in situ-generated B-H catalyst gave (S)-chroman-4-ols. Azide inversion and reduction gave crude (R)-chroman-4-amines, which could be purified without chromatography by isolation as the (R)-mandelic or D-tartaric acid salts with good yields and excellent ee. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.006