N,N-Dimethyl-(2E,4E)hexadienamin | 71570-78-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-Dimethyl-(2E,4E)hexadienamin
• 英文别名: (2E,4E)-N,N-dimethylhexa-2,4-dien-1-amine
• CAS: 71570-78-0
• 化学式: C₈H₁₅N
• 分子量: 125.214
• InChiKey: OQNQVZSWWQGUQG-YTXTXJHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N,N-Dimethyl-(2E,4E)hexadienamin 生成 (E,E)-2,4-己二烯醛
  参考文献：
  名称：

  GANGLOFF, ANTHONY R.;JUDGE, THOMAS M.;HELQUIST, PAUL, J. ORG. CHEM., 55,(1990) N1, C. 3679-3682

  摘要：

  DOI：
• 作为产物：
  描述：

  1,1,2-trimethyl-1,2,3,6-tetrahydro-pyridinium; iodide 在 氢氧化钾 作用下， 生成 N,N-Dimethyl-(2E,4E)hexadienamin
  参考文献：
  名称：

  Pyridines as Precursors of Conjugated Diene Pheromones

  摘要：

  DOI：

  10.1055/s-1979-28734

文献信息

• GANGLOFF, ANTHONY R.;JUDGE, THOMAS M.;HELQUIST, PAUL, J. ORG. CHEM., 55,(1990) N1, C. 3679-3682
  作者：GANGLOFF, ANTHONY R.、JUDGE, THOMAS M.、HELQUIST, PAUL

  DOI：——

  日期：——
• POTENT IMMUNOSUPPRESSIVE AGENTS, DERIVATIVES AND USES
  申请人：Romo Daniel

  公开号：US20110053994A1

  公开（公告）日：2011-03-03

  Provided herein include compositions, all related stereoisomers as well as pharmaceutically acceptable salts provided as simplified analogs of pateamine A, in which the analogs generally are devoid of the C3-amino and C5-methyl groups, also referred to as desmethyl, desamino-pateamine A. Suitable analogs provide anticancer and antiproliferative effects in vivo and in vitro by a novel drugs mechanism of action described herein for pateamine A, including inhibition of eIF4A-dependent translation initiation. As with pateamine A, as described herein, suitable analogs cause cell cycle arrest or induce apoptosis in transformed cells. However, toxicity of such compounds to slow growing normal cells is low. In addition, such analogs, like pateamine A, target translation initiation factors and are useful as anticancer and antiproliferative agents in subjects in need thereof. Moreover, the analogs, like pateamine A, are valuable molecular probes for evalutaion of eukaryotic translation initiation and as lead compounds for development of improved anticancer agents.
• US8841285B2
  申请人：——

  公开号：US8841285B2

  公开（公告）日：2014-09-23
• Pyridines as Precursors of Conjugated Diene Pheromones
  作者：G. Decodts、G. Dressaire、Y. Langlois

  DOI：10.1055/s-1979-28734

  日期：——