3-hydroxy-16-methylene-17-oxo-17a-oxa-D-homo-estra-1,3,5(10)-triene | 95237-29-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: 3-hydroxy-16-methylene-17-oxo-17a-oxa-D-homo-estra-1,3,5(10)-triene
• CAS: 95237-29-9
• 化学式: C₁₉H₂₂O₃
• 分子量: 298.382
• InChiKey: KUICUXQOCHMSHY-VXNCWWDNSA-N

反应信息

• 作为产物：
  描述：

  Acetic acid (4aS,4bR,10bS,12aS)-3-[1-diethylamino-meth-(E)-ylidene]-12a-methyl-2-oxo-3,4,4a,4b,5,6,10b,11,12,12a-decahydro-2H-1-oxa-chrysen-8-yl ester 在 氢气 作用下， 生成 3-hydroxy-16-methylene-17-oxo-17a-oxa-D-homo-estra-1,3,5(10)-triene
  参考文献：
  名称：

  Synthesis and cytotoxic activity of estrogen α-methylene-δ-lactones

  摘要：

  Several estrogen derivatives containing the alpha-methylene-delta-lactone group as part of the D-ring were prepared as anti-tumor agents. The compounds were highly toxic towards HeLa S3 cells grown in culture.

  DOI：

  10.1016/0039-128x(84)90046-1