diethyl 7'-methyl-3-phenyl-2'H-spiro[indene-1,1'-naphthalene]-3',3'(4'H)-dicarboxylate | 1049796-25-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: diethyl 7'-methyl-3-phenyl-2'H-spiro[indene-1,1'-naphthalene]-3',3'(4'H)-dicarboxylate
• 英文别名: Diethyl 6-methyl-3'-phenylspiro[1,3-dihydronaphthalene-4,1'-indene]-2,2-dicarboxylate
• CAS: 1049796-25-9
• 化学式: C₃₁H₃₀O₄
• 分子量: 466.577
• InChiKey: ZEOIQIKCBVISSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  diethyl 2-(4-hydroxy-4,4-diphenylbut-2-ynyl)-2-(4-methylbenzyl)malonate 在 三氯化铁 作用下， 以 硝基甲烷 为溶剂， 以91%的产率得到diethyl 7'-methyl-3-phenyl-2'H-spiro[indene-1,1'-naphthalene]-3',3'(4'H)-dicarboxylate
  参考文献：
  名称：

  Controllable One-Step Synthesis of Spirocycles, Polycycles, and Di- and Tetrahydronaphthalenes from Aryl-Substituted Propargylic Alcohols

  摘要：

  A novel, convenient, and efficient method has been developed for selective synthesis of spirocycle, polycycle, and di- and tetrahydronaphthalene systems from aryl-substituted propargylic alcohols by FeCl(3)- or TsOH-catalyzed multiple activations of unsaturated C-C bonds and C-H bonds.

  DOI：

  10.1021/jo801210n

文献信息

• Controllable One-Step Synthesis of Spirocycles, Polycycles, and Di- and Tetrahydronaphthalenes from Aryl-Substituted Propargylic Alcohols
  作者：Wen Huang、Pengzhi Zheng、Zhengxing Zhang、Ruiting Liu、Zhenxia Chen、Xigeng Zhou

  DOI：10.1021/jo801210n

  日期：2008.9.1

  A novel, convenient, and efficient method has been developed for selective synthesis of spirocycle, polycycle, and di- and tetrahydronaphthalene systems from aryl-substituted propargylic alcohols by FeCl(3)- or TsOH-catalyzed multiple activations of unsaturated C-C bonds and C-H bonds.