7-chloro-1-(3-methylphenyl)-1,3-dihydroquinazoline-2,4-dione | 57397-89-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 7-chloro-1-(3-methylphenyl)-1,3-dihydroquinazoline-2,4-dione
• 英文别名: 7-chloro-1-m-tolyl-1H-quinazoline-2,4-dione；7-Chloro-1-(3-methylphenyl)-2,4(1H,3H)-quinazolinedione；7-chloro-1-(3-methylphenyl)quinazoline-2,4-dione
• CAS: 57397-89-4
• 化学式: C₁₅H₁₁ClN₂O₂
• 分子量: 286.718
• InChiKey: JLRXLPRCODEJGV-UHFFFAOYSA-N

物化性质

• 熔点：
  252-254 °C(Solv: ethanol (64-17-5))
• 密度：
  1.373±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-chloro-2-m-toluidino-benzoic acid 、 尿素 以20%的产率得到
  参考文献：
  名称：

  PASTOR G.; BLANCHARD C.; MONTGINOUL C.; TORREILLES E.; GIRAL L.; TEXIER A+, BULL. SOC. CHIM. FRANCE , 1975, NO 5-6, PART. 2, 1331-1338

  摘要：

  DOI：

文献信息

• 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors
  申请人：IDEAYA BIOSCIENCES, INC.

  公开号：US11046691B1

  公开（公告）日：2021-06-29

  Disclosed herein are certain 2-oxoquinazoline derivatives of Formula (IA): that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.

  本文公开了某些式（IA）的 2-氧代喹唑啉衍生物： 是蛋氨酸腺苷转移酶 2A (MAT2A)抑制剂。还公开了包含此类化合物的药物组合物，以及治疗可通过抑制 MAT2A 治疗的疾病（如癌症，包括以甲基硫代腺苷磷酸化酶（MTAP）活性降低或缺失为特征的癌症）的方法。
• 2-OXOQUINAZOLINE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS
  申请人：Ideaya Biosciences, Inc.

  公开号：EP3894396A1

  公开（公告）日：2021-10-20
• [EN] 2-OXOQUINAZOLINE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS<br/>[FR] DÉRIVÉS DE 2-OXOQUINAZOLINE UTILISÉS EN TANT QU'INHIBITEURS DE LA MÉTHIONINE ADÉNOSYLTRANSFÉRASE 2A
  申请人：IDEAYA BIOSCIENCES INC

  公开号：WO2020123395A1

  公开（公告）日：2020-06-18

  Disclosed herein are certain 2-oxoquinazoline derivatives of Formula (IA): (IA) that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.