1-Ethyl-7-hydroxy-2-methyl-1.2.3.4.9.10.11.12-octahydro-phenanthren-2-carbonsaeure | 109784-48-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 1-Ethyl-7-hydroxy-2-methyl-1.2.3.4.9.10.11.12-octahydro-phenanthren-2-carbonsaeure
• 英文别名: 1-Ethyl-7-hydroxy-2-methyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-2-carboxylic acid；1-ethyl-7-hydroxy-2-methyl-3,4,4a,9,10,10a-hexahydro-1H-phenanthrene-2-carboxylic acid
• CAS: 109784-48-7
• 化学式: C₁₈H₂₄O₃
• 分子量: 288.387
• InChiKey: GEGYYIFBFKSCPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Bone anabolic compounds and methods of use
  申请人：——

  公开号：US20030119800A1

  公开（公告）日：2003-06-26

  A variety of bone anabolic compounds are useful for maintaining and/or increasing bone mass, density, and/or strength in mammals. Preferred compounds enhance bone anabolic activity while minimizing or eliminating undesirable feminizing or masculinizing effects.

  多种骨骼增生化合物对于维持和/或增加哺乳动物的骨量、密度和/或强度是有用的。优选的化合物增强骨骼增生活性，同时最小化或消除不良的女性化或男性化效果。
• METHOD AND BIOSENSOR FOR DETECTING ANTIGEN
  申请人：EBARA CORPORATION

  公开号：EP1143251A1

  公开（公告）日：2001-10-10

  A sensor chip for surface plasmon resonance which has a thin metal film, an antibody against a substance with the steroid skeleton such as a steroid hormone, a sex hormone or an environmental hormone (excluding triazine compounds), and a fixation layer for fixing the antibody to the thin metal film; and a method for detecting an environmental hormone which involves the step of exposing the antibody in the above-mentioned sensor chip to a sample, the step of irradiating the thin metal film with light and the step of determining the intensity of the light reflected by the thin metal film. This method achieves a high sensitivity and an excellent selectivity.

  一种用于表面等离子体共振的传感器芯片，它具有一层金属薄膜，一种针对类固醇激素、性激素或环境激素（不包括三嗪化合物）等具有类固醇骨架的物质的抗体，以及一层用于将抗体固定在金属薄膜上的固定层；以及一种检测环境激素的方法，它包括将上述传感器芯片中的抗体暴露在样品中的步骤、用光照射金属薄膜的步骤和测定金属薄膜反射光强度的步骤。这种方法灵敏度高，选择性好。
• METHOD FOR DETECTING EXOGENOUS ENDOCRINE DISRUPTING CHEMICAL AND DETECTION APPARATUS
  申请人：Central Research Institute of Electric Power Industry

  公开号：EP1231468A1

  公开（公告）日：2002-08-14

  A method and an apparatus for conveniently detecting at a high sensitivity an extrinsic endocrine disrupter which is a so-called environmental hormone, and enabling detection at a high sensitivity of an extrinsic endocrine disrupter (environmental hormone) existing in the environment with a low concentration to be conveniently carried out. The present invention includes: a detection container (1) having an immobilized female sex hormone receptor (2) such as an immobilized estrogen receptor filled therein; a light source (3) for exciting the inside of the container; and a detector (4) detecting a fluorescence intensity in the detection container after excitation. A fluorescence intensity F0 detected when a fluorescent-labeled female sex hormone having a certain concentration is added into the detection container is compared with a fluorescence intensity F1 detected when a fluorescent-labeled female sex hormone having the same concentration and being mixed with a sample to be tested is added into the detection container, and it is determined that an environmental hormone exists in the sample if F1 < F0 is established. Further, the female sex hormone can be also detected by the antigen-antibody reaction utilizing an anti-hormone antibody relative to the female sex hormone.

  一种方便地高灵敏度检测所谓环境激素的外源性内分泌干扰物的方法和装置，可方便地高灵敏度检测存在于环境中的低浓度外源性内分泌干扰物（环境激素）。本发明包括：检测容器（1），其中装有固定化雌性激素受体（2），如固定化雌激素受体；光源（3），用于激发容器内部；以及检测器（4），用于检测激发后检测容器中的荧光强度。在检测容器中加入一定浓度的荧光标记雌性激素时检测到的荧光强度 F0 与在检测容器中加入与待测样品混合的相同浓度的荧光标记雌性激素时检测到的荧光强度 F1 进行比较，如果确定 F1 < F0，则确定样品中存在环境激素。此外，还可以通过抗原-抗体反应，利用相对于雌性性激素的抗激素抗体来检测雌性性激素。
• 頭皮頭髪用組成物
  申请人：株式会社資生堂

  公开号：JP2000044435A

  公开（公告）日：2000-02-15

  (57)【要約】\n【課題】 優れた養毛効果、脱毛防止効果、フケ・カユミ防止効果を有し、安全性に優れた頭皮頭髪用組成物を提供すること。\n【解決手段】 オレイルジメチルアミンオキシド及び／又はイソステアリルジメチルアミンオキシドと卵胞ホルモンとを含有することを特徴とする頭皮頭髪用組成物。

  (57) [摘要] n[主题事项] 提供一种用于头皮和头发的组合物，该组合物具有极佳的生发效果、防脱发效果、去屑和防茧效果以及极佳的安全性。\含有氧化油基二甲基胺和/或氧化异硬脂基二甲基胺和毛囊激素的头皮和头发用组合物。
• Therapeutic applications of estrogenic carboxylic acids
  申请人：Southern Illinois University

  公开号：US20040116398A1

  公开（公告）日：2004-06-17

  Provided are methods employing estrogenic compounds for: repressing weight gain or reducing weight in male patients; treating or preventing prostate cancer and peri- or post-menopausal symptoms; treating estrogen-responsive conditions that no longer respond to treatment with conventional steroidal estrogens; treating or preventing estrogen-responsive uterine cancer, breast cancer, and ovarian follicle atresia; inducing ovulation to increase fertility; oral contraception; treating or preventing diseases or conditions caused or prolonged by free radicals; treating or preventing cardiovascular disease, hyperlipidemia or hypercholesterolemia, and hyperglycemia; improving body fat distribution; and treating or preventing Alzheimer's disease, osteoporosis, and pattern baldness. Also provided are methods for treating or preventing prostatic diseases including benign prostate hyperplasia and other related conditions, androgen-responsive pathological conditions in males, and methods for male birth control and chemical castration, employing estrogenic carboxylic acids.

  本发明提供了采用雌激素化合物的方法，用于抑制男性患者体重增加或减轻体重；治疗或预防前列腺癌和围绝经期或绝经后症状；治疗对传统甾体雌激素治疗不再有反应的雌激素反应性疾病；治疗或预防雌激素反应性子宫癌、乳腺癌和卵巢滤泡闭锁；诱导排卵以提高生育能力；口服避孕药；治疗或预防由自由基引起或延长的疾病或病症；治疗或预防心血管疾病、高脂血症或高胆固醇血症和高血糖症；改善体内脂肪分布；以及治疗或预防老年痴呆症、骨质疏松症和斑秃。此外，还提供了利用雌激素羧酸治疗或预防前列腺疾病（包括良性前列腺增生和其他相关疾病）、男性雄激素反应性病理状况以及男性节育和化学阉割的方法。