N-(2,4-dichlorophenyl)-2-[(4-methoxybenzyl)amino]-4-oxo-3-(4-sulfamoylphenyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidine-6(4H)-carboxamide | 1016972-52-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(2,4-dichlorophenyl)-2-[(4-methoxybenzyl)amino]-4-oxo-3-(4-sulfamoylphenyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidine-6(4H)-carboxamide
• 英文别名: N-(2,4-dichlorophenyl)-2-[(4-methoxyphenyl)methylamino]-4-oxo-3-(4-sulfamoylphenyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
• CAS: 1016972-52-3
• 化学式: C₂₈H₂₆Cl₂N₆O₅S
• 分子量: 629.524
• InChiKey: JVMOLZLMRPAKNO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  42
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  155
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• COMPOUND HAVING BICYCLIC PYRIMIDINE STRUCTURE AND PHARMACEUTICAL COMPOSITION COMPRISING THE COMPOUND
  申请人：Dainippon Sumitomo Pharma Co., Ltd.

  公开号：EP2078719A1

  公开（公告）日：2009-07-15

  The present invention relates to a bicyclic pyrimidine compound of the following formula (I) or a salt thereof. wherein R1 is lower alkyl, cyclic lower alkyl. etc.; R2 is H, lower alkyl, lower alkenyl, etc.; R3 is H, lower alkyl, lower alkenyl, etc.; X is O, S or -N(R4)-; R4 is H or lower alkyl; or R2 and R4 may combine each other to form cyclic amino; Y is amido, keto, sulfonyl, etc.; R5 is H or lower alkyl; Z is O or S; m and n are 1 or 2. Said compound (I) or a salt thereof have MGAT inhibitory activity, and are useful as an agent for treatment or prophylaxis of adiposity, metabolic syndromes, hyperlipidemia, hyper neutral lipemia, hyper VLDL-mia, hyper fatty acidemia, diabetes mellitus, arteriosclerosis.

  本发明涉及下式（I）的双环嘧啶化合物或其盐。 其中 R1 是低级烷基、环状低级烷基等；R2 是 H、低级烷基、低级烯基等；R3 是 H、低级烷基、低级烯基等；X 是 O、S 或 -N(R4)-；R4 是 H 或低级烷基；或 R2 和 R4 可相互结合形成环状氨基；Y 是氨基、酮基、磺酰基等；R5 是 H 或低级烷基；Z 是 O 或 S；m 和 n 是 1 或 2。所述化合物(I)或其盐具有 MGAT 抑制活性，可用于治疗或预防肥胖症、代谢综合征、高脂血症、高中性脂血症、高 VLDL-血症、高脂肪酸血症、糖尿病、动脉硬化。
• Compound having bicyclic pyrimidine structure and pharmaceutical composition comprising the same
  申请人：Nakamura Keiji

  公开号：US20100093771A1

  公开（公告）日：2010-04-15

  The present invention relates to a bicyclic pyrimidine compound of the following formula (I) or a salt thereof. wherein R 1 is lower alkyl, cyclic lower alkyl. etc.; R 2 is H, lower alkyl, lower alkenyl, etc.; R 3 is H, lower alkyl, lower alkenyl, etc.; X is O, S or —N(R 4 )—; R 4 is H or lower, alkyl; or R 2 and R 4 may combine each other to form cyclic amino; Y is amido, keto, sulfonyl, etc.; R 5 is H or lower alkyl; Z is O or S; m and n are 1 or 2. Said compound (I) or a salt thereof have MGAT inhibitory activity, and are useful as an agent for treatment or prophylaxis of adiposity, metabolic syndromes, hyperlipidemia, hyper neutral lipemia, hyper VLDL-mia, hyper fatty acidemia, diabetes mellitus, arteriosclerosis.
• US8232282B2
  申请人：——

  公开号：US8232282B2

  公开（公告）日：2012-07-31