(R)-N-cyclopropyl-3-[N-(2,2-dimethyl-1-oxoindan-5-yl)-N-(3-(3-hydroxypyrrolidin-1-yl)propyl)amino]-4-methylbenzamide | 918335-54-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (R)-N-cyclopropyl-3-[N-(2,2-dimethyl-1-oxoindan-5-yl)-N-(3-(3-hydroxypyrrolidin-1-yl)propyl)amino]-4-methylbenzamide
• 英文别名: N-cyclopropyl-3-[(2,2-dimethyl-1-oxo-3H-inden-5-yl)-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propyl]amino]-4-methylbenzamide
• CAS: 918335-54-3
• 化学式: C₂₉H₃₇N₃O₃
• 分子量: 475.631
• InChiKey: OGAXNGKYTXYSPB-XMMPIXPASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  72.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Bicyclic Derivatives as P38 Inhibitors
  申请人：Almansa Rosales Carmen

  公开号：US20100222363A1

  公开（公告）日：2010-09-02

  New bicyclic derivatives of formula (I); wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as p38 kinase inhibitors.

  公式（I）的新双环衍生物；其中各取代基的含义如描述中所披露。这些化合物可用作p38激酶抑制剂。
• Method of Controlling the Proliferation of Vascular Endothelial Cells and Inhibiting Lumen Formation
  申请人：Tokuda Masaaki

  公开号：US20080306011A1

  公开（公告）日：2008-12-11

  [PROBLEMS] To find out a specific rare sugar having effects of inhibiting the proliferation of vascular endothelial cells and lumen formation and utilize these effects. To provide this rare sugar as a preventive/remedy for diseases with angiogenesis, a cosmetic or a functional food. [MEANS FOR SOLVING PROBLEMS] A method of controlling the proliferation of vascular endothelial cells characterized by utilizing the vascular endothelial cell proliferation-controlling effect of D-mannose, D-allose, 2-deoxy-D-glucose, 3-deoxy-D-glucose, L-sorbose, 2-deoxy-D-ribose and/or 2-deoxy-L-ribose. A method of inhibiting lumen formation of vascular endothelial cells characterized by utilizing the vascular endothelial cell lumen formation-inhibiting effect of D-allose, D-altrose, D-gulose, D-talose, L-allose, 2-deoxy-D-glucose, 3-deoxy-D-glucose, D-ribose, L-ribose, 2-deoxy-D-ribose and/or 2-deoxy-L-ribose.

  [问题]：寻找一种具有抑制血管内皮细胞增殖和腔形成作用的特定稀有糖，并利用这些作用。提供这种稀有糖作为预防/治疗具有血管生成的疾病、化妆品或功能性食品。 [解决问题的方法]：使用D-甘露糖、D-异洛糖、2-脱氧-D-葡萄糖、3-脱氧-D-葡萄糖、L-山梨糖、2-脱氧-D-核糖和/或2-脱氧-L-核糖的血管内皮细胞增殖控制作用，来控制血管内皮细胞的增殖。使用D-异洛糖、D-阿鲁糖、D-古洛糖、D-他洛糖、L-异洛糖、2-脱氧-D-葡萄糖、3-脱氧-D-葡萄糖、D-核糖、L-核糖、2-脱氧-D-核糖和/或2-脱氧-L-核糖的血管内皮细胞腔形成抑制作用，来抑制血管内皮细胞的腔形成。
• METHOD OF CONTROLLING THE PROLIFERATION OF VASCULAR ENDOTHELIAL CELLS AND INHIBITING LUMEN FORMATION
  申请人：Tokuda Masaaki

  公开号：US20100222285A1

  公开（公告）日：2010-09-02

  A specific rare sugar having effects of inhibiting the proliferation of vascular endothelial cells and lumen formation is disclosed. This rare sugar is provided as a preventive/remedy for diseases with angiogenesis, a cosmetic or a functional food. The proliferation of vascular endothelial cells is controlled utilizing the vascular endothelial cell proliferation-controlling effect of D-mannose, D-allose, 2-deloxy-D-glucose, 3-deoxy-D-glucose, L-sorbose, 2-deoxy-D-ribose and/or 2-deoxy-L-ribose. Lumen formation of vascular endothelial cells is inhibited by utilizing the vascular endothelial cell lumen formation-inhibiting effect of D-allose, D-altrose, D-glucose, D-talose, L-allose, 2-deloxy-D-glucose, 3-deoxy-D-glucose, D-ribose, L-ribose, 2-deoxy-D-ribose and/or 2-deoxy-L-ribose.

  本文披露了一种特定的罕见糖，具有抑制血管内皮细胞增殖和腔形成的作用。该罕见糖可作为预防/治疗血管生成相关疾病、化妆品或功能性食品提供。利用D-甘露糖、D-异鼠李糖、2-去氧-D-葡萄糖、3-去氧-D-葡萄糖、L-山梨糖、2-去氧-D-核糖和/或2-去氧-L-核糖的血管内皮细胞增殖控制作用来控制血管内皮细胞的增殖。利用D-异葡萄糖、D-海藻糖、D-葡萄糖、D-赖糖、L-异鼠李糖、2-去氧-D-葡萄糖、3-去氧-D-葡萄糖、D-核糖、L-核糖、2-去氧-D-核糖和/或2-去氧-L-核糖的血管内皮细胞腔形成抑制作用来抑制血管内皮细胞的腔形成。