7-amino-2-methylisoquinolin-1(2H)-one | 54931-59-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 7-amino-2-methylisoquinolin-1(2H)-one
• 英文别名: 7-Amino-2-methyl-1,2-dihydroisoquinolin-1-one；7-amino-2-methylisoquinolin-1-one
• CAS: 54931-59-8
• 化学式: C₁₀H₁₀N₂O
• 分子量: 174.202
• InChiKey: IFEZWBRGVNSRGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] DIARYLHYDANTOIN DERIVATIVE, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF<br/>[FR] DÉRIVÉ DE DIARYLHYDANTOÏNE ET PROCÉDÉ DE PRÉPARATION, COMPOSITION PHARMACEUTIQUE ET UTILISATION CORRESPONDANTS
  申请人：SHANGHAI PHARMACEUTICALS HOLDING CO LTD

  公开号：WO2015018356A1

  公开（公告）日：2015-02-12

  本发明公开了二芳基乙内酰脲衍生物、其制备方法、药物组合物和应用。本发明提供了一种如式I所示的二芳基乙内酰脲衍生物、其药学上可接受的盐、溶剂化物、代谢产物、立体异构体、互变异构体、多晶型物或其药物前体，本发明的二芳基乙内酰脲衍生物对于治疗雄激素受体相关疾病，特别是去势耐受型前列腺癌有着良好的效果。
• ANTIMICROBIAL COMPOUNDS, COMPOSITIONS, AND USES THEREOF
  申请人：Lakewood Amedex, Inc.

  公开号：US20210139522A1

  公开（公告）日：2021-05-13

  Antimicrobial compounds and compositions of Formulas (I) to (III) and methods of use are disclosed. Another aspect of the present disclosure provides a pharmaceutical composition comprising a compound according to Formula (I) to (III), or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable carriers, excipients, or diluents. Another aspect of the present disclosure provides a method of treating a bacterial infection in a patient in need thereof, the method of comprising administering an effective amount of a compound according to Formula (I) to (III), or a pharmaceutically acceptable salt thereof, to the patient.