N-(4-bromo-2-fluorophenyl)-6-d3-methoxy-7-(piperidin-4-yl-d2-methoxy)quinazolin-4-amine | 1174683-78-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(4-bromo-2-fluorophenyl)-6-d3-methoxy-7-(piperidin-4-yl-d2-methoxy)quinazolin-4-amine
• 英文别名: N-(4-bromo-2-fluorophenyl)-7-[dideuterio(piperidin-4-yl)methoxy]-6-(trideuteriomethoxy)quinazolin-4-amine
• CAS: 1174683-78-3
• 化学式: C₂₁H₂₂BrFN₄O₂
• 分子量: 466.294
• InChiKey: HTCPERSEGREUFC-JIZANVDTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  68.3
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] VANDETANIB DERIVATIVES<br/>[FR] DÉRIVÉS DE VANDETANIB
  申请人：CONCERT PHARMACEUTICALS INC

  公开号：WO2009094210A1

  公开（公告）日：2009-07-30

  This invention relates to novel quinazoline derivatives and their acceptable acid addition salts. The invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions beneficially treated by inhibitory activity against the VEGF receptor tyrosine kinase.