Spiro- | 29959-25-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Spiro-
• 英文别名: (10R,13S)-10,13-dimethylspiro[1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-17,2'-1,3-dioxolane]
• CAS: 29959-25-9
• 化学式: C₂₁H₃₂O₂
• 分子量: 316.484
• InChiKey: BVEYNGJVGWLIBR-OQPPHWFISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  23
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Spiro- 生成 6β-Hydroxy-5β-androstan-17-on
  参考文献：
  名称：

  类固醇的构象自由能差异。第五部分。D环中结构修饰的5α-和5β-雄甾烷-6-一衍生物的平衡

  摘要：

  在环D中17β-基团（甲氧基，乙酰氧基，乙基或1,5-二甲基己基）的存在或不饱和对取代的5α-和5β-雄甾烷-6-之间的平衡位置影响很小。

  DOI：

  10.1039/j39700002421

文献信息

• Compositions relating to vitamin D
  申请人：Siemens Healthcare Diagnostics Inc.

  公开号：US10399938B2

  公开（公告）日：2019-09-03

  The present invention discloses compositions that comprise compounds relating to vitamin D. These compounds are useful for assays in the determination and distinguishing of certain 3-epimeric 25 hydroxyvitamin D and non-epimeric 25 hydroxyvitamin D. The compositions of the present invention may be used for example as immunogens used to develop antibodies to certain vitamin D compounds or conjugates used in assays for certain vitamin D compounds or used as a solid phase reagent in assays. The composition comprises a compound of one or more of the generic formula (R1)p-(L)q-Z.

  本发明公开了包含与维生素D有关的化合物的组合物，这些化合物可用于测定和区分某些3-表聚25羟基维生素D和非表聚25羟基维生素D。本发明的组合物可用作例如用于开发某些维生素D化合物抗体的免疫原，或用于测定某些维生素D化合物的共轭物，或用作测定中的固相试剂。本发明组合物包含一种或多种通式（R1）p-（L）q-Z 的化合物。
• BINDING PARTNERS SPECIFIC FOR VITAMIN D EPIMERS IN VITAMIN D ASSAYS
  申请人：Siemens Healthcare Diagnostics Inc.

  公开号：EP3161005B1

  公开（公告）日：2020-11-25
• ASSAYS FOR VITAMIN D EPIMERS
  申请人：Siemens Healthcare Diagnostics Inc.

  公开号：EP3161006B1

  公开（公告）日：2019-03-13
• COMPOSITIONS RELATING TO VITAMIN D
  申请人：Siemens Healthcare Diagnostics Inc.

  公开号：EP3177297B1

  公开（公告）日：2021-04-07
• BINDING PARTNERS SPECIFIC FOR VITAMIN D EPIMERS
  申请人：Siemens Healthcare Diagnostics Inc.

  公开号：US20170121426A1

  公开（公告）日：2017-05-04

  Antibodies are raised against compounds of Formula (I) where Z is an immunogenic carrier. These compounds are capable of binding specifically to corresponding antibodies. The antibodies are specific for epimers of vitamin D. Antibodies in accordance with the principles described herein may be employed to minimize or eliminate 3-epimer cross-reactivity in assays for non-epimeric forms of vitamin D analytes. Over-estimation of total non-epimeric vitamin D analyte caused by the cross-reactivity of 3-epimer vitamin D with an antibody for vitamin D analyte can be substantially avoided employing, as blocking agents, antibodies prepared against immunogens that are a compound of the Formula (I) wherein Z is an immunogenic carrier.