| 1242337-68-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• CAS: 1242337-68-3
• 化学式: C₁₄H₁₂O₄
• 分子量: 244.247
• InChiKey: GVKKBDLGLHBBRR-ZZXKWVIFSA-N

反应信息

• 作为产物：
  描述：

  3-hydroxy-2-(propen-1-yl)benzopyran-4-one 、 乙酸酐 在 吡啶 作用下， 反应 1.5h， 以72%的产率得到
  参考文献：
  名称：

  Synthesis and docking studies on styryl chromones exhibiting cytotoxicity in human breast cancer cell line

  摘要：

  The search for small molecules that preferentially target the functionally important surfaces of estrogen receptor and disrupt the transcriptional activity in the cell has emerged as a promising area towards rationale based drug design. Herein, we report substituted styryl chromones as a new class of compounds that exhibit selectivity for ER beta binding at the second binding site of HT and antiproliferative activity in human breast cancer cell line. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.05.108