(E)-11-(5-chlorothiophen-2-yl)-3-fluoro-N-isobutyldibenzo[b,f][1,4]thiazepine-8-carboxylic acid | 1019840-15-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫氮卓类
• 英文名称: (E)-11-(5-chlorothiophen-2-yl)-3-fluoro-N-isobutyldibenzo[b,f][1,4]thiazepine-8-carboxylic acid
• 英文别名: 6-(5-chlorothiophen-2-yl)-9-fluoro-N-(2-methylpropyl)benzo[b][1,4]benzothiazepine-3-carboxamide
• CAS: 1019840-15-3
• 化学式: C₂₂H₁₈ClFN₂OS₂
• 分子量: 444.981
• InChiKey: WIIMDXDKVMLDPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  95
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• CB-1 MODULATING COMPOUNDS AND THEIR USE
  申请人：Olsson Roger

  公开号：US20080090805A1

  公开（公告）日：2008-04-17

  Disclosed herein is a compound of Formula (I). Also disclosed herein is a method of modulating the activity of a cannabinoid receptor using a compound of Formula (I). Furthermore, disclosed herein is a method of treating a disease or condition that would be alleviated, improved or prevented by administration of a compound that modulates a cannabinoid receptor comprising identifying a subject in need thereof and administering to said subject a therapeutically effective amount of a compound of Formula (I). Also disclosed herein are pharmaceutical compositions comprising a compound of Formula (I).

  本文披露了一种化合物的结构式(I)。同时也披露了使用结构式(I)的化合物调节大麻素受体活性的方法。此外，还披露了一种治疗疾病或症状的方法，该疾病或症状可以通过给予调节大麻素受体的化合物得到缓解、改善或预防，包括确定需要该方法的受试者，并向该受试者施用结构式(I)的化合物的治疗有效量。本文还披露了包含结构式(I)的药物组合物。