4-[1-羟基-2-(丙-2-基氨基)丁基]苯-1,2-二醇盐酸盐 | 50-96-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 4-[1-羟基-2-(丙-2-基氨基)丁基]苯-1,2-二醇盐酸盐
• 中文别名: 异丙肾上腺素盐酸盐；盐酸异丙肾上腺素；4-[(2-异丙氨基-1-羟基)乙基]-1,2-苯二酚盐酸盐
• 英文名称: isoetharine hydrochloride
• 英文别名: 1-(3,4-dihydroxy-phenyl)-2-isopropylamino-butan-1-ol; hydrochloride；1-(3,4-Dihydroxy-phenyl)-2-isopropylamino-butan-1-ol; Hydrochlorid；hydron;4-[1-hydroxy-2-(propan-2-ylamino)butyl]benzene-1,2-diol;chloride
• CAS: 50-96-4
• 化学式: C₁₃H₂₁NO₃*ClH
• 分子量: 275.776
• InChiKey: MUFDLGGSOCHQOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.33
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  72.7
• 氢给体数：
  5
• 氢受体数：
  4

安全信息

• 海关编码：
  2922509090

制备方法与用途

异茶碱（盐酸盐）（化合物I）是一种选择性的、短期作用且可口服的β-激动剂，在吸入治疗的研究中常被用作支气管扩张剂。

文献信息

• 1,3-Bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders
  申请人：——

  公开号：US20030232877A1

  公开（公告）日：2003-12-18

  The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula 1 or its pharmaceutically acceptable salt or ester, wherein the substituents are defined in the application.

  这项发明涉及通式1的化合物、药物组合物和使用该化合物的方法，其中取代基在申请中定义。
• Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients
  申请人：Rogers D. Robin

  公开号：US20070093462A1

  公开（公告）日：2007-04-26

  Disclosed are ionic liquids and methods of preparing ionic liquid compositions of active pharmaceutical, biological, nutritional, and energetic ingredients. Also disclosed are methods of using the compositions described herein to overcome polymorphism, overcome solubility and delivery problems, to control release rates, add functionality, enhance efficacy (synergy), and improve ease of use and manufacture.

  揭示了离子液体及制备活性药物、生物、营养和能量成分的离子液体组合物的方法。还揭示了利用本文描述的组合物的方法，以克服多型性、克服溶解度和输送问题、控制释放速率、增加功能性、增强功效（协同作用）以及改善易用性和制造工艺。
• Dendrimers as molecular translocators
  申请人：Goodman Murray

  公开号：US20060216265A1

  公开（公告）日：2006-09-28

  Transport molecules include a dendrimer and a biologically active molecule. The dendrimer of such transport molecules includes at least one guanidine group, at least one protonated guanidine group, at least one protected guanidine group, at least one amidine group, at least one protonated amidine group, at least one protected amidine group, at least one ureido group, at least one protonated ureido group, at least one protected ureido group, at least one thioureido group, at least one protonated thioureido group, or at least one protected thioureido group. The biologically active molecule is bonded to the dendrimer. A method of increasing the bioavailability of a drug includes bonding the drug to a dendrimer of the invention.

  转运分子包括一种树枝状聚合物和一种生物活性分子。这些转运分子的树枝状聚合物包括至少一个胍基团、至少一个质子化的胍基团、至少一个保护的胍基团、至少一个酰胺基团、至少一个质子化的酰胺基团、至少一个保护的酰胺基团、至少一个脲基团、至少一个质子化的脲基团、至少一个保护的脲基团、至少一个硫脲基团、至少一个质子化的硫脲基团，或至少一个保护的硫脲基团。生物活性分子与树枝状聚合物结合。一种增加药物生物利用度的方法包括将药物与本发明的树枝状聚合物结合。
• [EN] DUAL FUNCTIONING IONIC LIQUIDS AND SALTS THEREOF<br/>[FR] LIQUIDES IONIQUES À DOUBLE FONCTION ET SELS DE CEUX-CI
  申请人：UNIV ALABAMA

  公开号：WO2010078300A1

  公开（公告）日：2010-07-08

  Disclosed herein are ionic liquid compositions comprising active pharmaceutical, biological, and nutritional compounds, and methods of use. Further disclosed are compositions of matter including liquid ion pairs alone or in solution and their use; compositions of ionic liquids that are 'solvated,' for example, 'hydrated' and their uses.

  本文揭示了包括活性药物、生物学和营养化合物的离子液体组合物，以及其使用方法。进一步揭示了包括液态离子对的物质组合物，单独或溶解后使用；以及离子液体的“溶剂化”组合物，例如“水合”的组合物及其用途。
• [EN] NANOPARTICLE FORMULATIONS AND USES THEROF<br/>[FR] FORMULATIONS DE NANOPARTICULES ET LEURS UTILISATIONS
  申请人：ABRAXIS BIOSCIENCE LLC

  公开号：WO2010118365A1

  公开（公告）日：2010-10-14

  The present invention provides compositions comprising nanoparticles comprising: 1) a drug, such as a hydrophobic drug derivative; and 2) a carrier protein. Also provided are methods of treating diseases (such as cancer) using the compositions, as well as kits and unit dosages.

  本发明提供了包含纳米粒子的组合物，其中包括：1）药物，如疏水性药物衍生物；和2）载体蛋白。还提供了使用这些组合物治疗疾病（如癌症）的方法，以及套件和单元剂量。