[2-(2-Aminoethoxy)ethyl](propan-2-yl)amine | 129509-04-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: [2-(2-Aminoethoxy)ethyl](propan-2-yl)amine
• 英文别名: N-[2-(2-aminoethoxy)ethyl]propan-2-amine
• CAS: 129509-04-2
• 化学式: C₇H₁₈N₂O
• mdl: MFCD21935007
• 分子量: 146.23
• InChiKey: FRKZWCMEYFKGNM-UHFFFAOYSA-N

物化性质

• 沸点：
  210.1±15.0 °C(Predicted)
• 密度：
  0.895±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  47.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] MACROCYCLIC LIGANDS WITH PENDANT CHELATING MOIETIES AND COMPLEXES THEREOF<br/>[FR] LIGANDS MACROCYCLIQUES AYANT DES FRACTIONS CHÉLATANTES PENDANTES ET LEURS COMPLEXES
  申请人：LUMIPHORE INC

  公开号：WO2019173639A1

  公开（公告）日：2019-09-12

  The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.

  这项发明涉及与金属离子形成的配体和配合物，在各种应用中有用，包括治疗和诊断应用。
• HETEROCYCLIC COMPOUNDS AND USES THEREOF AS D-ALANYL-D-ALANINE LIGASE INHIBITORS
  申请人：Moe T. Scott

  公开号：US20080090847A1

  公开（公告）日：2008-04-17

  The invention is based on the discovery of a new class of heterocyclic compounds having, for example, antibacterial properties. The D-Ala-D-Ala ligase enzyme is a critical pathway enzyme in the bacterial cell-wall synthesis. The compounds can bind to and inhibit the enzyme D-Ala-D-Ala ligase. The new compounds' activity combined with their ability to cross bacterial cell membranes makes them suitable for use as antibacterial drugs or other antibacterial applications.

  该发明基于发现一种新型杂环化合物类，例如具有抗菌特性。D-Ala-D-Ala连接酶酶是细菌细胞壁合成的关键途径酶。这些化合物可以结合并抑制D-Ala-D-Ala连接酶酶。新化合物的活性结合其穿过细菌细胞膜的能力，使它们适用于用作抗菌药物或其他抗菌应用。
• [EN] AROMATIC ENOL ETHERS<br/>[FR] ÉTHERS D'ÉNOL AROMATIQUES
  申请人：EASTMAN CHEM CO

  公开号：WO2022125856A1

  公开（公告）日：2022-06-16

  Disclosed are aromatic enol ether compounds that have utility as film- hardening additives for coating formulations. The aromatic enol ether compounds have particular utility as film-hardening additives for water-based coating formulations. The aromatic enol ether compounds provide improvements in hardness and hardness related properties such as block resistance, without contributing to the volatile organic content of the coating formulation.

  本发明涉及一种芳香烯醇醚化合物，其可用作涂料配方的膜硬化添加剂。该芳香烯醇醚化合物在水性涂料配方中作为膜硬化添加剂具有特殊的实用性。该芳香烯醇醚化合物提供了硬度和硬度相关性能的改进，如阻塞抗性，而不会增加涂料配方的挥发性有机物含量。
• POLY (BETA-AMINO ESTERS) AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20190125874A1

  公开（公告）日：2019-05-02

  Provided herein are branched poly(beta-amino esters) (PBAE) useful as vehicles for the delivery of therapeutic agents, such as nucleic acids. The disclosed polymers form stable compositions, and are suitable for the delivery of therapeutic agents via nebulization. Compositions of the disclosed polymers are capable of delivering therapeutic agents such as mRNA to lung epithelial cells.
• INHIBITION OF OLIG2 ACTIVITY
  申请人：Curtana Pharmaceuticals, Inc.

  公开号：US20210253535A1

  公开（公告）日：2021-08-19

  Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of Olig2. Also described herein are methods of using such Olig2 inhibitors, alone and in combination with other compounds, for treating cancer and other diseases. In particular the Olig2 inhibitors may be used to treat glioblastoma.