4-methyl-2-(2-methyl-2-octadecylicosyl)-1-(2l5-propa-1,2-dien-2-yl)benzene | 128925-29-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-methyl-2-(2-methyl-2-octadecylicosyl)-1-(2l5-propa-1,2-dien-2-yl)benzene
• CAS: 128925-29-1
• 化学式: C₄₄H₈₂N₂O₃
• 分子量: 687.147
• InChiKey: ZLESBHDEZKDYBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.14
• 重原子数：
  49.0
• 可旋转键数：
  37.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  66.2
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  N,N-Dioctadecyl-N-methyl-N-<4-nitro-1-(benzoyloxy)-3-benzyl>ammonium bromide 在 谷胱甘肽 、 Tris buffer 、 potassium chloride 作用下， 以 盐酸 、 氯仿 为溶剂， 生成 4-methyl-2-(2-methyl-2-octadecylicosyl)-1-(2l5-propa-1,2-dien-2-yl)benzene
  参考文献：
  名称：

  表面分化合成双层膜中表面活性剂单体结构与触发器动力学的关系

  摘要：

  在这里，我们证明可以类似地研究由结构不同的合成表面活性剂构成的双层囊泡，并且单体结构可以很容易地与膜内的触发器动力学相关联

  DOI：

  10.1021/ja00173a034

文献信息

• A hydrolytic reporter of copper(II) availability in artificial liposomes
  作者：Giovanna Ghirlanda、Paolo Scrimin、Paolo Tecilla、Umberto Tonellato

  DOI：10.1021/jo00063a020

  日期：1993.5

  The dioctadecyl ammonium surfactant 1, functionalized with a p-nitrophenyl ester of picolinic acid, has been synthesized and its hydrolysis in covesicular blends of nonfunctional surfactants dihexadecyldimethylammonium bromide, 3, dioctadecyldimethylammonium bromide, 4, and racemic 1,2-bis(palmitoyloxy)-3-(trimethylammonium)propyl bromide, 5, studied after addition of Cu(II) ions at pH = 5.0 and different temperatures. The cleavage of 1 gives the p-nitrophenoxide surfactant 2, which shows a strong absorption band at 400 nm. Clear biphasic kinetics were observed for all vesicular systems at a temperature below the gel-to-liquid crystal phase transition temperature (T(c)) of the membrane: the first, faster process (almost-equal-to 60% of the ester cleaved) was associated with the Cu(II)-catalyzed hydrolysis of the exovesicular ester; the slower one (the remaining almost-equal-to 40% of the ester cleaved) was associated with the uncatalyzed hydrolysis of the endovesicular ester. Above T(c) only a monoexponential process was observed. Variable temperature experiments allowed one to conclude that the cationic vesicles studied are totally impermeable to Cu(II) ions either below or above their T(c) which controls the rate of the transbilayer movements of the lipids.