2-(4-bromo-7-chloro-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid | 1082208-11-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: 2-(4-bromo-7-chloro-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid
• CAS: 1082208-11-4
• 化学式: C₉H₄BrClN₂O₃
• 分子量: 303.499
• InChiKey: ZEVDHJKNIHJGSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  草酰氯单乙酯 、 4-溴-7-氯-1H-吡咯并[2,3-c]吡啶 在 1-ethyl-3-methylimidazolium chloroaluminate 作用下， 反应 18.0h， 以93%的产率得到2-(4-bromo-7-chloro-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid
  参考文献：
  名称：

  An efficient one-pot synthesis of 3-glyoxylic acids of electron-deficient substituted azaindoles by ionic liquid imidazolium chloroaluminate-promoted Friedel–Crafts acylation

  摘要：

  An efficient, one-pot Friedel-Crafts acylation/hydrolysis reaction promoted by the acidic ionic liquid 1-ethyl-3-methylimidazolium chloroaluminate (generated from 1-ethyl-3-methylimidazolium chloride (EmimCl) and aluminum chloride (X(AlCl(3)), Mole fraction X = 0.75) for the formation of 3-glyoxylic acid derivatives of electron-deficient, substituted 4- and 6-azaindoles is described. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.08.045

文献信息

• INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC 4-ALKENYL PIPERIDINE AMIDES
  申请人：Wang Tao

  公开号：US20080188481A1

  公开（公告）日：2008-08-07

  This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with new piperidine 4-alkenyl derivatives that possess unique antiviral activity. More particularly, the present invention relates to compounds useful for the treatment of HIV and AIDS. The compounds of the invention for the general Formula I: wherein: Z is Q is selected from the group consisting of: —W— is

  本发明提供了具有药物和生物影响性质的化合物，它们的制药组合物和使用方法。具体而言，本发明涉及具有独特的抗病毒活性的新的哌啶4-烯基衍生物。更具体地，本发明涉及用于治疗HIV和艾滋病的化合物。本发明的化合物一般公式为I：其中：Z是Q是从以下组中选择的：-W-是
• US7915283B2
  申请人：——

  公开号：US7915283B2

  公开（公告）日：2011-03-29
• An efficient one-pot synthesis of 3-glyoxylic acids of electron-deficient substituted azaindoles by ionic liquid imidazolium chloroaluminate-promoted Friedel–Crafts acylation
  作者：Kap-Sun Yeung、Zhilei Qiu、Michelle E. Farkas、Qiufen Xue、Alicia Regueiro-Ren、Zhong Yang、John A. Bender、Andrew C. Good、John F. Kadow

  DOI：10.1016/j.tetlet.2008.08.045

  日期：2008.10

  An efficient, one-pot Friedel-Crafts acylation/hydrolysis reaction promoted by the acidic ionic liquid 1-ethyl-3-methylimidazolium chloroaluminate (generated from 1-ethyl-3-methylimidazolium chloride (EmimCl) and aluminum chloride (X(AlCl(3)), Mole fraction X = 0.75) for the formation of 3-glyoxylic acid derivatives of electron-deficient, substituted 4- and 6-azaindoles is described. (C) 2008 Elsevier Ltd. All rights reserved.