2,5-bis(4-carboxyphenyl)furan | 194298-15-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: 2,5-bis(4-carboxyphenyl)furan
• 英文别名: 4-[5-(4-Carboxyphenyl)furan-2-yl]benzoic acid
• CAS: 194298-15-2
• 化学式: C₁₈H₁₂O₅
• 分子量: 308.29
• InChiKey: OWPMFASVYHBTKC-UHFFFAOYSA-N

物化性质

• 沸点：
  540.3±50.0 °C(Predicted)
• 密度：
  1.352±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,5-bis(4-carboxyphenyl)furan 在 氯化亚砜 作用下， 以 苯 为溶剂， 反应 2.5h， 以84%的产率得到2,5-bis[4-carboxyphenyl]furan diacid chloride
  参考文献：
  名称：

  2,5-Bis[4-(N-alkylamidino)phenyl]furans as Anti-Pneumocystis carinii Agents

  摘要：

  The syntheses of 12 new 2,5-bis[4-(N-alkylamidino)phenyl]furans are reported. The interaction of these dicationic furans with poly(dA-dT) and with the duplex oligomer d(CGCGAATTCGCG)(2) was determined by T-m measurements, and the effectiveness of these compounds against the immunosuppressed rat model of Pneumocystis carinii was evaluated. At the screening dose of 10 mu mol/kg, 9 of the 14 N-alkylamidino furans described here are more active than the parent compound 1. Substitution of an alkyl group on the amidino nitrogen, except for in 9, 13, and 15, resulted in higher affinity for DNA than the parent compound as judged by the larger Delta T-m values and suggests enhanced van der Waals interact ions in the bis-amidine-DNA complex. Five of the compounds, 3, 5, 7, 10, and 12, yield cyst counts of less than 0.1% of control when administered at a dosage of 10 mu mol/kg. Five compounds, 1, 6, 8, 10, and 12, show significant activity at a dosage of approximately 1 mu mol/kg; 12 is the most active derivative, and it is approximately 100 times more effective than pentamidine in this animal model.

  DOI：

  10.1021/jm970570i
• 作为产物：
  描述：

  4,4'-(2,5-呋喃二基)二-苯甲腈 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 40.0h， 以75%的产率得到2,5-bis(4-carboxyphenyl)furan
  参考文献：
  名称：

  2,5-Bis[4-(N-alkylamidino)phenyl]furans as Anti-Pneumocystis carinii Agents

  摘要：

  The syntheses of 12 new 2,5-bis[4-(N-alkylamidino)phenyl]furans are reported. The interaction of these dicationic furans with poly(dA-dT) and with the duplex oligomer d(CGCGAATTCGCG)(2) was determined by T-m measurements, and the effectiveness of these compounds against the immunosuppressed rat model of Pneumocystis carinii was evaluated. At the screening dose of 10 mu mol/kg, 9 of the 14 N-alkylamidino furans described here are more active than the parent compound 1. Substitution of an alkyl group on the amidino nitrogen, except for in 9, 13, and 15, resulted in higher affinity for DNA than the parent compound as judged by the larger Delta T-m values and suggests enhanced van der Waals interact ions in the bis-amidine-DNA complex. Five of the compounds, 3, 5, 7, 10, and 12, yield cyst counts of less than 0.1% of control when administered at a dosage of 10 mu mol/kg. Five compounds, 1, 6, 8, 10, and 12, show significant activity at a dosage of approximately 1 mu mol/kg; 12 is the most active derivative, and it is approximately 100 times more effective than pentamidine in this animal model.

  DOI：

  10.1021/jm970570i

文献信息

• Process for fluorimetric monitoring of functional coatings and structures used in the process and comprising a substrate and said functional coating
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0336029A1

  公开（公告）日：1989-10-11

  A method for monitoring the coating weight, uniformity, defects or markings present in a coating of a composition applied to a substrate comprises the steps: a) providing a substrate with a functional coating of a composition comprising an effective amount of uvescer that absorbs radiant energy, i.e., has an excitation energy, of wavelength λ1 and emits radiant energy of wavelength λ2; b) scanning the coating with radiant energy having a wavelength within wavelength λ1 ; c) detecting the radiant energy of wavelength X2 emitted by the coating; and d) optionally, correlating the emitted radiant energy to independently measured standard coating weights or thicknesses, of the coating so as to measure coating weight, thickness, uniformity, defects, or markings.

  一种用于监测涂在底材上的组合物涂层的重量、均匀性、缺陷或标记的方法包括以下步骤： a) 向基底提供由有效量的vescer 组成的功能性组合物涂层，该vescer 可吸收波长为 λ1 的辐射能，即具有激发能，并发射波长为 λ2 的辐射能； b) 用波长在波长 λ1 范围内的辐射能扫描涂层； c) 检测涂层发射的波长为 X2 的辐射能；以及 d) 可选地将发射的辐射能与独立测量的涂层标准重量或厚度相关联，以测量涂层重量、厚度、均匀性、缺陷或标记。
• ANTIFUNGAL ACTIVITY OF DICATIONIC MOLECULES
  申请人：UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

  公开号：EP1143959B1

  公开（公告）日：2006-11-02
• US4922113A
  申请人：——

  公开号：US4922113A

  公开（公告）日：1990-05-01
• US4978731A
  申请人：——

  公开号：US4978731A

  公开（公告）日：1990-12-18
• US5087670A
  申请人：——

  公开号：US5087670A

  公开（公告）日：1992-02-11