7H,15H-8,16-methanodinaphtho[1,2-b:1',2'-f][1,5]diazocine | 1193457-08-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 7H,15H-8,16-methanodinaphtho[1,2-b:1',2'-f][1,5]diazocine
• 英文别名: 1,13-Diazahexacyclo[11.11.1.02,11.03,8.014,23.015,20]pentacosa-2(11),3,5,7,9,14(23),15,17,19,21-decaene；1,13-diazahexacyclo[11.11.1.02,11.03,8.014,23.015,20]pentacosa-2(11),3,5,7,9,14(23),15,17,19,21-decaene
• CAS: 1193457-08-7；1193457-09-8；1193457-10-1
• 化学式: C₂₃H₁₈N₂
• 分子量: 322.409
• InChiKey: OZRLSJPWPUKDKG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  25
• 可旋转键数：
  0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 1-萘胺 在 三氟乙酸 、 氨 作用下， 以 水 为溶剂， 反应 24.0h， 以26%的产率得到7H,15H-8,16-methanodinaphtho[1,2-b:1',2'-f][1,5]diazocine
  参考文献：
  名称：

  Enantioseparations of non-benzenoid and oligo-Tröger’s bases by HPLC on Whelk O1 column

  摘要：

  The separation of enantiomers of several 'bis- and tris-Troger's bases' by HPLC on commercially available chiral stationary phase Whelk O1 is described for the first time. The observed structure-enantioselectivity relationships are in agreement with the previously established molecular recognition model. For all 'bis- and tris-Troger's bases' studied, satisfactory to excellent enantioselectivities were observed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.07.036

文献信息

• Enantioseparations of non-benzenoid and oligo-Tröger’s bases by HPLC on Whelk O1 column
  作者：Sergey Sergeyev、Sara Stas、Adrienne Remacle、Christophe M.L. Vande Velde、Bohumil Dolenský、Martin Havlík、Vladimír Král、Jan Čejka

  DOI：10.1016/j.tetasy.2009.07.036

  日期：2009.8

  The separation of enantiomers of several 'bis- and tris-Troger's bases' by HPLC on commercially available chiral stationary phase Whelk O1 is described for the first time. The observed structure-enantioselectivity relationships are in agreement with the previously established molecular recognition model. For all 'bis- and tris-Troger's bases' studied, satisfactory to excellent enantioselectivities were observed. (C) 2009 Elsevier Ltd. All rights reserved.