2-(2-bromophenoxy)-3-phenyl-6-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | 1240709-67-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 2-(2-bromophenoxy)-3-phenyl-6-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one
• CAS: 1240709-67-4
• 化学式: C₂₇H₁₉BrF₃N₅O₂
• 分子量: 582.379
• InChiKey: ZJMHQFIHTCVUFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  38
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  73.8
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• [EN] PYRIMIDIN-4(3H)-ONE DERIVATIVES<br/>[FR] DÉRIVÉS DE PYRIMIDIN-4(3H)-ONE
  申请人：BANYU PHARMA CO LTD

  公开号：WO2010095767A1

  公开（公告）日：2010-08-26

  The present invention relates to a compound represented by a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1 represents lower alkyl or the like; R2 represents phenyl or the like; R represents a halogen atom or the like; X represents an oxygen atom or the like; Y1, Y2, Y3 and Y4 represent CH or the like; l represents an integer of from 0 to 3; m and n each represent an integer of 1 or 2; p represents an integer of from 0 to 2; and q represents an integer of from 1 to 3.

  本发明涉及一种由式(I)表示的化合物或其药学上可接受的盐，其中R1代表低碳烷基或类似物; R2代表苯基或类似物; R代表卤素原子或类似物; X代表氧原子或类似物; Y1、Y2、Y3和Y4代表CH或类似物; l表示0到3的整数; m和n各表示1或2的整数; p表示0到2的整数; q表示1到3的整数。
• PYRIMIDIN-4-(3H)-ONE DERIVATIVES
  申请人：Arakawa Keisuke

  公开号：US20110275647A1

  公开（公告）日：2011-11-10

  The present invention relates to a compound represented by a formula (I): or a pharmaceutically acceptable salt thereof, wherein R 1 represents lower alkyl or the like; R 2 represents phenyl or the like; R represents a halogen atom or the like; X represents an oxygen atom or the like; Y 1 , Y 2 , Y 3 and Y 4 represent CH or the like; l represents an integer of from 0 to 3; m and n each represent an integer of 1 or 2; p represents an integer of from 0 to 2; and q represents an integer of from 1 to 3.

  本发明涉及一种由式（I）表示的化合物或其药学上可接受的盐，其中R1代表较低的烷基或类似物；R2代表苯基或类似物；R代表卤素原子或类似物；X代表氧原子或类似物；Y1、Y2、Y3和Y4代表CH或类似物；l表示0到3的整数；m和n各代表1或2的整数；p表示0到2的整数；q表示1到3的整数。