3β.17-dihydroxy-21-nor-5α.17βH-pregnanoic acid-(20) | 125078-64-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3β.17-dihydroxy-21-nor-5α.17βH-pregnanoic acid-(20)
• 英文别名: 3β,17α-dihydroxy-5α-androstan-17β-carboxylic acid；3β.17-dihydroxy-21-nor-5α-pregnanoic acid-(20)；3β.17α-Dihydroxy-5α-androstan-carbonsaeure-(17β)；3β.17-Dihydroxy-21-nor-5α-pregnansaeure-(20)
• CAS: 125078-64-0
• 化学式: C₂₀H₃₂O₄
• 分子量: 336.472
• InChiKey: WSDYDRRFTFZSMO-WVCYWSPPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.21
• 重原子数：
  24.0
• 可旋转键数：
  1.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  77.76
• 氢给体数：
  3.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  3β.17-dihydroxy-21-nor-5α.17βH-pregnanoic acid-(20) 在 吡啶 、 乙醚 作用下， 生成 17-hydroxy-3β-acetoxy-21-nor-5α-pregnanoic acid-(20)-methyl ester
  参考文献：
  名称：

  比利时国家经济和发展史托夫分校。（25. Mitteilung）。异戊酸-pregnan-二醇-（3,17）-衍生物der 17（β）-Reihe。实物模型与实物研究（17）-Reihe

  摘要：

  DOI：

  10.1002/hlca.19390220190
• 作为产物：
  描述：

  17β-Ethinyl-3β-acetoxy-5α-androstan-17α-ol 在 甲醇 、 四氯化碳 、 potassium carbonate 、 臭氧 作用下， 生成 3β.17-dihydroxy-21-nor-5α.17βH-pregnanoic acid-(20)
  参考文献：
  名称：

  比利时国家经济和发展史托夫分校。（25. Mitteilung）。异戊酸-pregnan-二醇-（3,17）-衍生物der 17（β）-Reihe。实物模型与实物研究（17）-Reihe

  摘要：

  DOI：

  10.1002/hlca.19390220190

文献信息

• Preparation and biological activity of androstane 17β-carboxylic acids
  作者：M. L. Gerasimova、T. I. Gusarova、V. B. Nikitin、G. N. Engalycheva、M. É. Kaminka、E. F. Kuleshova

  DOI：10.1007/bf00764615

  日期：1989.11
• Über Bestandteile der Nebennierenrinde und verwandte Stoffe. (29. Mitteilung). Einwirkung von Bleitetra-acetat auf Allopregnanolon-acetat, Pregnenolon-acetat und Progesteron
  作者：T. Reichstein、C. Montigel

  DOI：10.1002/hlca.193902201155

  日期：——
• Über Bestandteile der Nebennierenrinde. 19. Mitteilung. Die Substanzen N und P, sowie Beobachtungen zur Konfiguration am Kohlenstoffatom Nr. 17
  作者：T. Reichstein、K. Gätzi

  DOI：10.1002/hlca.193802101148

  日期：——
• Age-Related Variations of Elements as Compared Among Optic, Radial, and Sciatic Nerves
  作者：Yoshiyuki Tohno、Yasuo Takano、Setsuko Tohno、Yumi Moriwake、Takeshi Minami、Fumio Nishiwaki、Masa-Oki Yamada、Masako Utsumi、Kazunari Yuri

  DOI：10.1385/bter:77:2:119

  日期：——

  To elucidate changes of peripheral nerves with aging, the authors studied age-related changes of element contents in the optic, radial, and sciatic nerves by inductively coupled plasma-atomic emission spectrometry. The subjects consisted of seven men and seven women, ranging in age from 61 to 97 yr. The contents of phosphorus and sulfur remained constant through ages 61 to 97 yr in three nerves, the optic, radial, and sciatic nerves. It was found that there were age-related differences in calcium content among the optic, radial, and sciatic nerves: The calcium content of the optic nerve increased progressively with aging; in the radial nerve, it was hardly changed with aging; in contrast, the calcium content of the sciatic nerve decreased gradually with aging. In addition, it was found that in the radial nerve there were moderate correlations between age and zinc or sodium content, whereas significant correlations between age and the content of silicon or iron were found in the sciatic nerve. Furthermore, there was a correlation between the silicon and iron contents in the sciatic nerves.