4-Cyanoinden | 29005-27-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: 4-Cyanoinden
• 英文别名: 4-Cyaninden；1H-indene-4-carbonitrile
• CAS: 29005-27-4
• 化学式: C₁₀H₇N
• 分子量: 141.172
• InChiKey: YLLUWFAJIWETMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] COMPOUNDS USEFUL FOR TREATING GASTROINTESTINAL TRACT DISORDERS<br/>[FR] COMPOSÉS UTILES POUR LE TRAITEMENT DE TROUBLES DU TRACTUS DIGESTIF
  申请人：ARDELYX INC

  公开号：WO2018129552A1

  公开（公告）日：2018-07-12

  The present disclosure is directed to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-stage renal disease, liver disease, and peroxisome proliferator-activated receptor (PPAR) gamma agonist- induced fluid retention. The present disclosure is also directed to compounds and methods for the treatment of hypertension. The present disclosure is also directed to compounds and methods for the treatment of gastrointestinal tract disorders, including the treatment or reduction of pain associated with gastrointestinal tract disorders.

  本公开涉及化合物和治疗与液体潴留或盐过多有关的疾病的方法，例如心力衰竭（特别是充血性心力衰竭）、慢性肾病、晚期肾病、肝病和过氧化物酶体增殖物激活受体（PPAR）γ激动剂诱导的液体潴留。本公开还涉及化合物和治疗高血压的方法。本公开还涉及化合物和治疗胃肠道疾病的方法，包括治疗或减轻与胃肠道疾病相关的疼痛。
• [EN] INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS<br/>[FR] INDAZOLES ET AZAINDAZOLES EN TANT QU'INHIBITEURS DE LRRK2
  申请人：ESCAPE BIO INC

  公开号：WO2021178780A1

  公开（公告）日：2021-09-10

  The present invention is directed to indazole and azaindazole compounds which are inhibitors of LRRK2 and are useful in the treatment of CNS disorders.

  本发明涉及一种抑制LRRK2的吲唑和杂氮吲唑化合物，可用于治疗中枢神经系统疾病。
• [EN] SUBSTITUTED AMINO-PYRIMIDINES<br/>[FR] AMINO-PYRIMIDINES SUBSTITUÉES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2021249892A1

  公开（公告）日：2021-12-16

  The invention provides novel compounds having the general formula (I), wherein R1, R2, and R3 are as defined herein, compositions including the compounds and methods of using the compounds.

  本发明提供了具有一般式（I）的新化合物，其中R1，R2和R3如本文所定义，包括该化合物的组合物和使用该化合物的方法。
• NOVEL MODULATORS OF SPHINGOSINE PHOSPHATE RECEPTORS
  申请人：The Scripps Research Institute

  公开号：EP2291080A1

  公开（公告）日：2011-03-09
• INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2427444A1

  公开（公告）日：2012-03-14