(E)-N-(2-amino-phenyl)-3-{4-[(4-cyano-phenylcarbamoyl)-((S)-3-hydroxy-pyrrolidin-1-yl)-methyl]-phenyl}-acrylamide | 1195965-75-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (E)-N-(2-amino-phenyl)-3-{4-[(4-cyano-phenylcarbamoyl)-((S)-3-hydroxy-pyrrolidin-1-yl)-methyl]-phenyl}-acrylamide
• 英文别名: (E)-N-(2-aminophenyl)-3-[4-[2-(4-cyanoanilino)-1-[(3S)-3-hydroxypyrrolidin-1-yl]-2-oxoethyl]phenyl]prop-2-enamide
• CAS: 1195965-75-3
• 化学式: C₂₈H₂₇N₅O₃
• 分子量: 481.554
• InChiKey: NBOZIYKUJLZDES-QNXIMQPPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  36
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  132
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• NOVEL N-(2-AMINO-PHENYL)-ACRYLAMIDES
  申请人：Wong Jason Christopher

  公开号：US20090286848A1

  公开（公告）日：2009-11-19

  The present invention is directed to the compounds of formula wherein R 1 to R 4 have the significances given herein, to processes for the manufacture of said compounds as well as medicaments containing said compounds. The compounds according to this invention show anti-proliferative and differentiation-inducing activity and are thus useful for the treatment of diseases such as cancer in humans or animals.

  本发明涉及具有以下式的化合物，其中R1至R4具有本文中给出的含义，以及制造该化合物的方法以及含有该化合物的药物。根据本发明的化合物显示抗增殖和诱导分化活性，因此对于治疗人类或动物的癌症等疾病是有用的。
• US7999000B2
  申请人：——

  公开号：US7999000B2

  公开（公告）日：2011-08-16
• [EN] NOVEL N-(2-AMINO-PHENYL)-ACRYLAMIDES<br/>[FR] NOUVEAUX N-(2-AMINO-PHÉNYL)-ACRYLAMIDES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2009138338A1

  公开（公告）日：2009-11-19

  The present invention is directed to the compounds of formula (I), wherein R1 to R4 have the significances given herein, to processes for the manufacture of said compounds as well as medicaments containing said compounds. The compounds according to this invention show anti-proliferative and differentiation-inducing activity and are thus useful for the treatment of diseases such as cancer in humans or animals.