1-Corbasil; 3-Amino-1-(3,4-dihydroxy-phenyl)propan-1-ol | 20228-13-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 1-Corbasil; 3-Amino-1-(3,4-dihydroxy-phenyl)propan-1-ol
• 英文别名: 4-(3-Amino-1-hydroxypropyl)benzene-1,2-diol
• CAS: 20228-13-1
• 化学式: C₉H₁₃NO₃
• 分子量: 183.207
• InChiKey: GBTKPTAZJPGVEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  86.7
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• [EN] ADMINISTRATION OF AN ALPHA-2 ADRENERGIC RECEPTOR AGONIST TO ENHANCE CARDIOPULMONARY RESUSCITATION<br/>[FR] ADMINISTRATION D'UN AGONISTE DE ALPHA-2 RECEPTEUR ADRENERGIQUE DESTINEE A AMELIORER LA REANIMATION CARDIO-PULMONAIRE
  申请人：INST CRITICAL CARE MEDICINE

  公开号：WO2001039761A1

  公开（公告）日：2001-06-07

  Methods, formulations and kits are described for resuscitating a patient suffering from cardiac arrest, for enhancing the efficacy of cardiopulmonary resuscitation, for treating post-resuscitation hypotension, and for reducing the incidence of ventricular arrhythmias and myocardial dysfunction in a patient following cardiopulmonary resuscitation. Prior methods and agents often cause inotropic or chronotropic effects, which can lead to undesirable post-resuscitation myocardial dysfunction. The invention comprises administering a therapeutically effective amount of an α2-receptor agonist that does not cross the blood-brain barrier, such as α-methylnorepinephrine, to enhance cardiopulmonary resuscitation.