2-[2-[4-(6-fluoro-2H-indazol-3-yl)piperidin-1-yl]ethylamino]-3H-quinazolin-4-one | 873107-40-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-[2-[4-(6-fluoro-2H-indazol-3-yl)piperidin-1-yl]ethylamino]-3H-quinazolin-4-one
• CAS: 873107-40-5
• 化学式: C₂₂H₂₃FN₆O
• 分子量: 406.463
• InChiKey: RPLZWLOGKFDTOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  85.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Quinazoline Derivatives as Parp Inhibitors
  申请人：Guillemont Jerome Emile Georges

  公开号：US20080070915A1

  公开（公告）日：2008-03-20

  The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compnounds of formula (I) wherein R 1 , R 2 , R 3 , L, X, Y and Z have defined meanings.
• QUINAZOLINONE DERIVATIVES AS PARP INHIBITORS
  申请人：Janssen Pharmaceutica NV

  公开号：US20140080835A1

  公开（公告）日：2014-03-20

  The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R 1 , R 2 , R 3 , L, X, Y and Z have defined meanings.
• US8623872B2
  申请人：——

  公开号：US8623872B2

  公开（公告）日：2014-01-07
• US9522905B2
  申请人：——

  公开号：US9522905B2

  公开（公告）日：2016-12-20