tert-Butyl [(2R)-2-(6-chloro-3-pyridyl)-2-hydroxyethyl][2-(4-hydroxyphenyl)ethyl]carbamate | 643093-81-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: tert-Butyl [(2R)-2-(6-chloro-3-pyridyl)-2-hydroxyethyl][2-(4-hydroxyphenyl)ethyl]carbamate
• 英文别名: tert-Butyl [(2R)-2-(6-chloro-pyridin-3-yl)-2-hydroxyethyl][2-(4-hydroxyphenyl)ethyl]carbamate；tert-butyl N-[(2R)-2-(6-chloropyridin-3-yl)-2-hydroxyethyl]-N-[2-(4-hydroxyphenyl)ethyl]carbamate
• CAS: 643093-81-6
• 化学式: C₂₀H₂₅ClN₂O₄
• 分子量: 392.882
• InChiKey: SDJCBBLJGJDXPC-KRWDZBQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  82.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• AMINOALCOHOL DERIVATIVES
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP1546086A2

  公开（公告）日：2005-06-29
• [EN] AMINOALCOHOL DERIVATIVES<br/>[FR] DERIVES D'AMINOALCOOL
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2004002939A2

  公开（公告）日：2004-01-08

  The present invention relates to a compound formula [I]: Y is bond, -0-(CH2)n- (in which n is 1, 2, 3 or 4), etc., Z is cyano, tetrazolyl, etc., R1 is hydrogen, lower alkyl, etc., R2 is hydrogen or an amino protective group, R3 is hydrogen or lower alkyl, R4 is hydrogen or lower alkyl,R5 and R8 are each independently hydrogen, halogen, hydroxy,lower alkyl, etc., R6 is hydrogen, lower alkyl, etc., R9 is hydrogen or lower alkyl, and i is 1 or 2,or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.