(S)-4-[(3-bromophenyl)amino]-6-[(pyrrolidine-2-yl)methoxy]-7-methoxyquinazoline | 295330-47-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: (S)-4-[(3-bromophenyl)amino]-6-[(pyrrolidine-2-yl)methoxy]-7-methoxyquinazoline
• 英文别名: N-(3-bromophenyl)-7-methoxy-6-[[(2S)-pyrrolidin-2-yl]methoxy]quinazolin-4-amine
• CAS: 295330-47-1
• 化学式: C₂₀H₂₁BrN₄O₂
• 分子量: 429.316
• InChiKey: AQSNIUOIRRQPMN-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  68.3
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Bicyclic heterocycles, pharmaceutical compositions containing them, their use, and processes for preparing them
  申请人：——

  公开号：US20020177601A1

  公开（公告）日：2002-11-28

  A compound of formula (I) 1 wherein R a , R b , R c , A, B, C, D, and X are as defined herein, or a tautomer, stereoisomer, or salt thereof, particularly a physiologically acceptable salt thereof. In addition, pharmaceutical compositions comprising an effective amount of a compound of formula (I), methods for the treatment or prophylaxis of benign or malignant tumors, diseases of the airways and lungs, polyps, diseases of the gastrointestinal tract, bile duct, gall bladder, kidneys, and skin, and methods for making compounds of formula (I) are disclosed.

  式（I）的化合物，其中Ra、Rb、Rc、A、B、C、D和X如本文所定义，或其互变异构体、立体异构体或盐，特别是其生理上可接受的盐。此外，还公开了包含式（I）化合物的药物组合物，用于治疗或预防良性或恶性肿瘤、呼吸道和肺部疾病、息肉、胃肠道、胆道、胆囊、肾脏和皮肤疾病的有效量，以及制备式（I）化合物的方法。
• BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, THEIR USE, AND PROCESSES FOR PREPARING THEM
  申请人：HIMMELSBACH Frank

  公开号：US20090203683A1

  公开（公告）日：2009-08-13

  A compound of formula (I) wherein R a , R b , R c , A, B, C, D, and X are as defined herein, or a tautomer, stereoisomer, or salt thereof, particularly a physiologically acceptable salt thereof. In addition, pharmaceutical compositions comprising an effective amount of a compound of formula (I), methods for the treatment or prophylaxis of benign or malignant tumors, diseases of the airways and lungs, polyps, diseases of the gastrointestinal tract, bile duct, gall bladder, kidneys, and skin, and methods for making compounds of formula (I) are disclosed.

  一种化合物的化学式为(I)，其中Ra、Rb、Rc、A、B、C、D和X的定义如本文所述，或其互变异构体、立体异构体或盐，特别是生理上可接受的盐。此外，还公开了包含化合物(I)有效量的药物组合物，用于治疗或预防良性或恶性肿瘤、呼吸道和肺部疾病、息肉、胃肠道、胆管、胆囊、肾脏和皮肤疾病的方法，以及制备化合物(I)的方法。
• BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, AND PROCESSES FOR PREPARING THEM
  申请人：Boehringer Ingelheim Pharma GmbH & Co.KG

  公开号：EP1163227B1

  公开（公告）日：2005-09-28