N-Methyl-3-amino-spiro<5,5>undecan | 3896-79-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-Methyl-3-amino-spiro<5,5>undecan
• 英文别名: N-methylspiro[5.5]undecan-3-amine
• CAS: 3896-79-5
• 化学式: C₁₂H₂₃N
• 分子量: 181.321
• InChiKey: XTKGYFCPDWNZCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-Formyl-3-amino-spiro<5,5>undecan 在 lithium aluminium tetrahydride 作用下， 生成 N-Methyl-3-amino-spiro<5,5>undecan
  参考文献：
  名称：

  尖顶。X.氨基螺烷。

  摘要：

  DOI：

  10.1021/jm00330a021

文献信息

• INHIBITION OF INFLUENZA M2 PROTON CHANNEL
  申请人：DeGrado William F.

  公开号：US20110288111A1

  公开（公告）日：2011-11-24

  Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.

  提供了一些化合物，这些化合物能够通过与M2跨膜蛋白相互作用来调节甲型流感病毒的活性。同时还提供了一种治疗甲型流感受影响的疾病状态或感染的方法，包括给予含有已被鉴定为能够与M2蛋白相互作用的一个或多个化合物的组合物。
• INFLUENZA A VIRUS INHIBITION
  申请人：DeGrado William F.

  公开号：US20110294785A1

  公开（公告）日：2011-12-01

  Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.
• ORGANO-TRANSITION METAL COMPLEXES FOR THE TREATMENT OF VIRAL INFECTIONS
  申请人：BUSATH David D.

  公开号：US20170128489A1

  公开（公告）日：2017-05-11

  Organo-transition metal complexes possess anti-viral inhibitory activity against influenza A, including the S3 IN mutant. The organo-transition metal complexes include a transition metal and at least one ligand based on the structure of an M2 proton channel blocker. Compounds and pharmaceutical compositions are useful for treating viruses such as influenza A.
• US9453005B2
  申请人：——

  公开号：US9453005B2

  公开（公告）日：2016-09-27
• US9464075B2
  申请人：——

  公开号：US9464075B2

  公开（公告）日：2016-10-11