LiC6H4-o-OH | 72332-11-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: LiC6H4-o-OH
• CAS: 72332-11-7
• 化学式: C₆H₅LiO
• 分子量: 100.046
• InChiKey: XIKJSNFBRJOQEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.19
• 重原子数：
  8.0
• 可旋转键数：
  0.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  LiC6H4-o-OH 、 三苯基氯化锡 以 乙醚 为溶剂， 以57%的产率得到(C6H5)3SnC6H4-o-OH
  参考文献：
  名称：

  Arntzen, C. E., Iowa State College Journal of Science, 1943, vol. 18, p. 6 - 9

  摘要：

  DOI：
• 作为产物：
  描述：

  2-溴苯酚 、 正丁基锂 生成 LiC6H4-o-OH
  参考文献：
  名称：

  WIFE, R. L.;OORT, A. B. VAN;DOORN, J. A. VAN;LEEUWEN, P. W. N. M. VAN, SYNTHESIS, BRD, 1983, N 1, 71-73

  摘要：

  DOI：

文献信息

• BIO-NANO POWER CELLS AND THEIR USES
  申请人：Long Nathan R.

  公开号：US20130330293A1

  公开（公告）日：2013-12-12

  The present invention concerns bio-nano power cells and methods of their manufacture and use. More particularly, the present invention relates to the preparation of bio-nano power cells that are biocompatible and capable of producing flash, intermittent, or continuous power by electrolyzing compounds in biological systems.

  这项发明涉及生物纳米电池及其制造和使用方法。更具体地，这项发明涉及制备生物纳米电池，这些电池具有生物相容性，并能够通过在生物系统中电解化合物来产生闪光、间歇或持续电力。
• [EN] VITAMIN D3 MIMICS<br/>[FR] SUBSTANCES MIMETIQUES DE VITAMINE D3
  申请人：LIGAND PHARM INC

  公开号：WO2000010958A1

  公开（公告）日：2000-03-02

  The present invention relates to non-secosteroidal compounds which activate and modulate the vitamin D receptor (VDR). Because the compounds of the present invention display many of the beneficial properties of 1,25(OH)2D3, but with reduced calcium mobilization effects, they may be used advantageously to treat and prevent conditions that show vitamin D sensitivity. Such disease states typically show abnormal calcium regulatory, abnormal immune responsive, hyperproliferative, and/or neurodegenerative characteristics.

  本发明涉及非类固醇化合物，其能够激活和调节维生素D受体（VDR）。由于本发明的化合物表现出许多1,25（OH）2D3的有益特性，但具有减少钙动员效应，因此它们可以有利地用于治疗和预防显示维生素D敏感性的疾病状态。这些疾病状态通常表现出异常的钙调节、异常的免疫响应、过度增殖和/或神经退行性特征。
• [EN] IMMUNOLOGICAL ADJUVANT COMPOUND<br/>[FR] COMPOSE D'ADJUVANT IMMUNOLOGIQUE
  申请人：EISAI CO LTD

  公开号：WO2000044758A1

  公开（公告）日：2000-08-03

  The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant formulations which include at least one of the adjuvant compounds of the invention, to novel immunostimulatory compositions which comprise an antigen and at least one of the adjuvant compounds of the invention, and to methods for the immunization of an animal by co-administration of a compound of the invention with an antigen against which the animal is to be immunized.

  本发明涉及新型化合物，当与细菌和病毒疾病的疫苗等抗原共同给药时，可作为免疫佐剂的功能。涉及至少包括本发明中的佐剂化合物之一的新型佐剂配方，涉及包括抗原和本发明中的佐剂化合物之一的新型免疫刺激组合物，以及通过与动物所需免疫的抗原共同给药本发明化合物的方法来免疫动物。
• Bridged Ring Structures as Pharmaceutical Agents
  申请人：Flatt T. Brenton

  公开号：US20070225377A1

  公开（公告）日：2007-09-27

  The present invention is directed to 1α,25-dihydroxyvitamin D3 mimics which modulate the vitamin D receptor (VDR). The invention is further directed to pharmaceutical compositions and methods for the treatment, prevention or amelioration of one or more symptoms of disease or disorder related to the activity of the vitamin D receptor using an effective amount of a compound of formula (I).

  本发明涉及一种模拟1α，25-二羟基维生素D3的化合物，可以调节维生素D受体（VDR）的活性。本发明还涉及使用公式（I）化合物的有效量的制药组合物和方法，用于治疗、预防或减轻与维生素D受体活性相关的一种或多种疾病或障碍的症状。
• Janus Dendrimers and Dendrons
  申请人：Tomalia Donald A.

  公开号：US20080221300A1

  公开（公告）日：2008-09-11

  This invention provides a cost effective process and new Janus dendrimers where at least two dendrons are attached at the core (with or without a connector group) and where at least two of the dendrons have different functionality. Preferred are those Janus dendrimers where at least one dendron is a PEHAM dendron. Thus these Janus dendrimers are heterobifunctional in character and use unique ligation chemistry with single site functional dendrons, di-dendrons and multi-dendrons. Also included are Janus dendrons which maybe used as intermediates to make the Janus dendrimers or to further react with another reactive moiety. These Janus dendrimers can provide several new dendrimer moieties, namely: combinatorial libraries of bifunctional structures; combined target director and signaling dendrimers; specific targeting entities for diagnostic and therapeutic applications, such as for example targeted MRI agents, targeted radionuclide delivery for diseases such as cancer, and targeted photosensitive or radiowave sensitive agents.

  该发明提供了一种经济有效的过程和新的Janus树状分子，其中至少有两个树枝附着在核心上（带有或不带有连接器组），并且至少有两个树枝具有不同的功能。首选的是至少一个树枝是PEHAM树枝的Janus树状分子。因此，这些Janus树状分子具有异双功能性质，并且使用具有单个位点功能树枝，二元树枝和多元树枝的独特连接化学。还包括可以用作制备Janus树状分子的中间体或进一步与另一反应性基团反应的Janus树枝。这些Janus树状分子可以提供几种新的树状分子基团，即：双功能结构的组合库；结合目标指向和信号传导的树状分子；用于诊断和治疗应用的特定靶向实体，例如用于靶向MRI剂、针对癌症等疾病的靶向放射性核素传递和靶向光敏或辐射波敏感剂。