2(3-p-hydroxyphenyl-1-methylpropyl)amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene | 75305-20-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 2(3-p-hydroxyphenyl-1-methylpropyl)amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene
• 英文别名: 6-[4-(4-Hydroxyphenyl)butan-2-ylamino]-5,6,7,8-tetrahydronaphthalene-2,3-diol
• CAS: 75305-20-3
• 化学式: C₂₀H₂₅NO₃
• 分子量: 327.423
• InChiKey: SEVVMFQGAQZCPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  72.7
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• 2-alpha-Methyl-dopaminimino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene, its salts, and a process for preparation thereof
  申请人：AMERICAN HOSPITAL SUPPLY CORPORATION

  公开号：EP0033789A1

  公开（公告）日：1981-08-19

  Derivatives of 2-amino-6,7-dihydroxytetrahydronaph- thalene (ADTN) represented by the formula wherein R is OH, alkyloxy, hydroxyalkyl or acyloxy, and R' is an aryl alkyl in which the aryl group is benzyl, substituted benzyl, phenyl or substituted phenyl and the alkyl group is a straight or branched chain alkyl having one to twenty carbon atoms, and the pharmaceutically acceptable salts thereof. These derivatives of 2-amino-6,7-dihydroxytetrahydro- naphthalene are useful as inotropes. The compounds may be prepared by reductive amination of the protected 2-amino-6,7-dihydroxytetrahydro- naphthalene.

  2-amino-6,7-dihydroxytetrahydronaph- thalene（ADTN）的衍生物，其代表式为 其中 R 是 OH、烷氧基、羟基烷基或酰氧基，R'是芳基烷基，其中芳基是苄基、取代苄基、苯基或取代苯基，烷基是具有一至二十个碳原子的直链或支链烷基，以及它们的药学上可接受的盐类。 这些 2-氨基-6,7-二羟基四氢-萘的衍生物可用作肌力促进剂。 这些化合物可通过受保护的 2-氨基-6,7-二羟基四氢-萘的还原胺化反应制备。
• US4314082A
  申请人：——

  公开号：US4314082A

  公开（公告）日：1982-02-02
• US5096929A
  申请人：——

  公开号：US5096929A

  公开（公告）日：1992-03-17
• [EN] DERIVATIVES OF 2-AMINO-6,7-DIHYDROXYTETRAHYDRONAPHTHALENE(ADTN)
  申请人：——

  公开号：WO1980000251A1

  公开（公告）日：1980-02-21

  (EN) Derivatives of 2-amino-6,7-dihydroxytetrahydronaphthalene (ADTN) represented by the formula (FORMULA) wherein R is OH, alkyloxy, hydroxyalkyl or acyloxy, and R" is an arylalkyl where the aryl group is benzyl, substituted benzyl, phenyl or substituted phenyl and the alkyl group is a straight or branched chain alkyl having one to twenty carbon atoms; and the pharmaceutically acceptable salts thereof. These derivatives of 2-amino-6,7-dihydroxytetrahydronaphthalene are useful as inotropes. (FR) Derives de 2-amino-6,7-dihydroxytetrahydronaphthalene (ADTN) representes par la formule (FORMULE) ou R est OH, aldyloxy, hydroxyalkyle ou acyloxy, et R" est un arylalkyle ou le groupe aryle est le benzyle, le benzyle substitue, le phenyle ou le phenyle substitue, et le groupe alkyle est un alkyle a chaine droite ou ramifiee ayant un a vingt atomes de carbone; et leurs sels pharmaceutiquement acceptables. Ces composes de 2-amino-6,7-dihydroxytetrahydronaphthalene sont utiles comme inotropes.