8-diethylamino-1-octylamine | 103706-76-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 8-diethylamino-1-octylamine
• 英文别名: N',N'-diethyloctane-1,8-diamine
• CAS: 103706-76-9
• 化学式: C₁₂H₂₈N₂
• 分子量: 200.368
• InChiKey: XILBIKIKPJCBSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  8-diethylamino-1-octylamine 生成 2-Amino-4-(2,5-dichlorophenyl)-6-(8-diethylamino-1-octylamino)-1,3,5-triazine
  参考文献：
  名称：

  Triazine derivative and medicine

  摘要：

  该发明涉及一种药物组合物，其包括以下一般式的三嗪衍生物\x9bI! ##STR1## 或其溶剂化物，或其盐，作为活性成分。在上述式中，R.sup.1和R.sup.2可以相同也可以不同，每个代表氢，未取代或取代的烷基芳基，或烯基，或者共同代表与相邻氮原子结合的环状氨基（NR.sup.1 R.sup.2）。该环状氨基除了相邻氮原子外，还可以包含氮、氧或硫作为环成员，并且可能进一步取代。不包括NR.sup.1 R.sup.2为NH.sub.2的情况。该发明的化合物可用作治疗肝炎的治疗药物。

  公开号：

  US05962453A1

文献信息

• Catalyst for production of a polyurethane resin and method for producing a polyurethane resin
  申请人：——

  公开号：US20030088046A1

  公开（公告）日：2003-05-08

  Polyurethane resins are produced by reacting a polyol with a polyisocyanate in the presence of an amine catalyst of one of the formulae: 1

  聚氨酯树脂是通过在一种胺催化剂的存在下，将聚醇与聚异氰酸酯反应而制得的，该胺催化剂的化学式之一为：1
• Catalyst for production of a polyurethane resin and method for producting a polyurethane resin
  申请人：Tosoh Corporation

  公开号：US20040147705A1

  公开（公告）日：2004-07-29

  A method for producing a polyurethane resin, which comprises reacting a polyol with a polyisocyanate in the presence of a catalyst selected from the group consisting of a catalyst (A) containing an amine compound of the following formula (1): 1 wherein each of R 1 and R 2 which are independent of each other, is a C 1-4 alkyl group, and A is a C 5-10 straight chain or branched chain alkylene group; a catalyst (B) containing an amine compound of the following formula (2): 2 a catalyst (C) containing an amine compound of the following formula (3): 3 a catalyst (D) containing a compound of the following formula (5): 4 wherein each of R 3 , R 4 and R 5 which are independent of one another, is a hydrogen atom or a C 1-4 alkyl group, R 6 is a hydrogen atom, a functional group of the following formula: 5 wherein R 7 is a hydrogen atom or a C 1-4 alkyl group, and p is an integer of from 1 to 3, or a 3-aminopropyl group, and an amine compound of the following formula (6): 6 wherein X is a nitrogen atom or an oxygen atom, each of R 8 and R 9 which are independent of each other, is a methyl group or a functional group of the following formula: 7 wherein R 10 is a hydrogen atom or a C 1-4 alkyl group, and q is an integer of from 1 to 3, and each of m and n is an integer of from 1 to 2, provided that when X is a nitrogen atom, R 8 and R 9 are not simultaneously methyl groups, and that when X is an oxygen atom, R 9 is a functional group of the following formula: 8 wherein R 10 is a hydrogen atom or a C 1-4 alkyl group, and q is an integer of from 1 to 3; and a catalyst (E) containing an amine compound of the following formula (7): 9 wherein each of R 11 , R 12 and R 13 which are independent of one another, is a hydrogen atom or a C 1-4 straight chain or branched chain alkyl group, and R 14 is a C 1-4 straight chain or branched chain alkylene group.

  一种制备聚氨酯树脂的方法，其包括在催化剂的存在下，将聚醇与聚异氰酸酯反应，所述催化剂从以下组中选择：催化剂（A）包含以下公式（1）的胺化合物：其中，R1和R2各自独立地是C1-4烷基，A是C5-10直链或支链烷基；催化剂（B）包含以下公式（2）的胺化合物：催化剂（C）包含以下公式（3）的胺化合物：催化剂（D）包含以下公式（5）的化合物：其中，R3、R4和R5各自独立地是氢原子或C1-4烷基，R6是氢原子，以下式子的功能基：其中，R7是氢原子或C1-4烷基，p是1到3之间的整数，或3-氨丙基基团，以及以下公式（6）的胺化合物：其中，X是氮原子或氧原子，R8和R9各自独立地是甲基或以下式子的功能基：其中，R10是氢原子或C1-4烷基，q是1到3之间的整数，m和n各自是1到2之间的整数，但当X是氮原子时，R8和R9不能同时为甲基，当X是氧原子时，R9是以下式子的功能基：其中，R10是氢原子或C1-4烷基，q是1到3之间的整数；以及催化剂（E）包含以下公式（7）的胺化合物：其中，R11、R12和R13各自独立地是氢原子或C1-4直链或支链烷基，R14是C1-4直链或支链烷基。
• TRIAZINE DERIVATIVE AND MEDICINE
  申请人：NIPPON SHINYAKU COMPANY, LIMITED

  公开号：EP0775487A1

  公开（公告）日：1997-05-28

  A medicine containing as the active ingredient a triazine derivative represented by general formula (I), a solvate thereof, or a salt thereof and being useful as a hepatitis remedy, wherein R1 and R2 represent each independently hydrogen or (un)substituted alkyl, aralkyl or alkenyl, or NR1R2 represents a cyclic amino group which may bear, in addition to the pertinent nitrogen atom, nitrogen, oxygen or sulfur as the ring atom and may be substituted, provided the case where NR1R2 represents NH2 is excluded.

  一种含有通式(I)代表的三嗪衍生物、其溶液或其盐作为有效成分并可用于治疗肝炎的药物，其中R1和R2各自独立地代表氢或(未)取代的烷基、芳烷基或烯基，或NR1R2代表环状氨基，其环状原子除了相关的氮原子外，还可以是氮、氧或硫，并且可以被取代，但不包括NR1R2代表NH2的情况。
• US5962453A
  申请人：——

  公开号：US5962453A

  公开（公告）日：1999-10-05
• US6723819B2
  申请人：——

  公开号：US6723819B2

  公开（公告）日：2004-04-20