3-(4-Methoxy-phenoxy)-1-aza-bicyclo[2.2.2]octane | 144328-90-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 奎宁环
• 英文名称: 3-(4-Methoxy-phenoxy)-1-aza-bicyclo[2.2.2]octane
• 英文别名: 3-(4-Methoxyphenoxy)-1-azabicyclo[2.2.2]octane
• CAS: 144328-90-5
• 化学式: C₁₄H₁₉NO₂
• 分子量: 233.31
• InChiKey: PGUYIDIRCFQGNV-UHFFFAOYSA-N

物化性质

• 沸点：
  346.6±22.0 °C(Predicted)
• 密度：
  1.14±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-甲氧基苯酚 、 奎宁环-3-醇 生成 3-(4-Methoxy-phenoxy)-1-aza-bicyclo[2.2.2]octane
  参考文献：
  名称：

  Dosing form for reagents, use of said dosing form in organic chemical synthesis and production of said dosing form

  摘要：

  提供了一种用于传统有机和无机合成、并行合成以及在组合化学中的分割和混合合成中使用的至少一种固体试剂的剂型，其为每个压缩片剂，每个压缩片剂包含相同预定量的至少一种试剂，嵌入在聚合物基质中，该聚合物基质包括不溶于预定合成溶剂的聚合物珠，这些片剂能够在所述溶剂中解体以释放至少一种试剂，并将基质分散为聚合物珠进入溶剂中。剂型的聚合物珠形成基质和试剂可以通过过滤轻松地从形成的可溶产品中分离出来。 在生产该剂型的方法中，将一种或多种聚合物的珠与试剂混合，并在用无水有机溶剂预处理后压缩成片剂。

  公开号：

  US20030138376A1

文献信息

• 3-Quinuclidine derivatives
  申请人：Akzo Nobel N.V.

  公开号：EP0497415A1

  公开（公告）日：1992-08-05

  The invention relates to a 3-quinuclidine derivative having the formula I wherein X is O or S, and R represents one to five substituents independently selected from hydrogen, hydroxy, lower alkyl, lower alkoxy, lower aralkyloxy, lower alkanoyloxy, halogen, NO₂, CF₃, CN, NR₁R₂, and COR₃, in which R₁ and R₂ are independently selected from hydrogen, lower alkyl, and lower alkanoyl, and R₃ is selected from OH, lower alkyl, lower alkoxy, and NR₄R₅, wherein R₄ and R₅ are independently hydrogen or lower alkyl; or pharmaceutically acceptable salts thereof.

  本发明涉及一种 3-奎宁环衍生物，其式为 I 其中 X 是 O 或 S，R 代表一至五个取代基，独立选自氢、羟基、低级烷基、低级烷氧基、低级芳氧基、低级烷酰氧基、卤素、NO₂、CF₃、CN、NR₁R₂ 和 COR₃、其中 R₁ 和 R₂ 独立选自氢、低级烷基和低级烷酰基，R₃ 选自 OH、低级烷基、低级烷氧基和 NR₄R₅，其中 R₄ 和 R₅ 独立为氢或低级烷基；或其药学上可接受的盐。
• DOSING FORM FOR REAGENTS, USE OF SAID DOSING FORM IN ORGANIC CHEMICAL SYNTHESIS AND PRODUCTION OF SAID DOSING FORM
  申请人：H. Lundbeck A/S

  公开号：EP1268051A2

  公开（公告）日：2003-01-02
• US5258392A
  申请人：——

  公开号：US5258392A

  公开（公告）日：1993-11-02
• [EN] DOSING FORM FOR REAGENTS, USE OF SAID DOSING FORM IN ORGANIC CHEMICAL SYNTHESIS AND PRODUCTION OF SAID DOSING FORM<br/>[FR] FORME DOSE POUR REACTIFS, UTILISATION DE CETTE FORME EN SYNTHESE ORGANIQUE ET PRODUCTION DE CETTE FORME DOSE
  申请人：LUNDBECK & CO AS H

  公开号：WO2001068599A2

  公开（公告）日：2001-09-20

  A dosing form for at least one solid reagent for use in conventional organic and inorganic synthesis, in parallel synthesis, and in split and mix synthesis in combinatorial chemistry is provided as compressed tablets each containing the same predetermined amount of said at least one reagent embedded in a polymer matrix comprising beads of a polymer insoluble in the solvents for the intended synthesis, which tablets are capable of disintegrating in said solvent for release of the at least one reagent and disperse the matrix as polymer beads into the solvent. The polymer beads forming the matrix and the reagents of the dosing form can easily be removed by filtration in order to separate these from a formed soluble product. In a method for producing the dosing form, beads of one or more polymers are mixed with the reagents and compressed into tablets after pre-treatment with an aprotic organic solvent.
• Dosing form for reagents, use of said dosing form in organic chemical synthesis and production of said dosing form
  申请人：H. Lundbeck A/S

  公开号：US20030138376A1

  公开（公告）日：2003-07-24

  A dosing form for at least one solid reagent for use in conventional organic and inorganic synthesis, in parallel synthesis, and in split and mix synthesis in combinatorial chemistry is provided as compressed tablets each containing the same predetermined amount of said at least one reagent embedded in a polymer matrix comprising beads of a polymer insoluble in the solvents for the intended synthesis, which tablets are capable of disintegrating in said solvent for release of the at least one reagent and disperse the matrix as polymer beads into the solvent. The polymer beads forming the matrix and the reagents of the dosing form can easily be removed by filtration in order to separate these from a formed soluble product. In a method for producing the dosing form, beads of one or more polymers are mixed with the reagents and compressed into tablets after pre-treatment with an aprotic organic solvent.

  提供了一种用于传统有机和无机合成、并行合成以及在组合化学中的分割和混合合成中使用的至少一种固体试剂的剂型，其为每个压缩片剂，每个压缩片剂包含相同预定量的至少一种试剂，嵌入在聚合物基质中，该聚合物基质包括不溶于预定合成溶剂的聚合物珠，这些片剂能够在所述溶剂中解体以释放至少一种试剂，并将基质分散为聚合物珠进入溶剂中。剂型的聚合物珠形成基质和试剂可以通过过滤轻松地从形成的可溶产品中分离出来。 在生产该剂型的方法中，将一种或多种聚合物的珠与试剂混合，并在用无水有机溶剂预处理后压缩成片剂。