1-((1R,3R,5S)-8-((1R,3r,5S)-bicyclo[3.3.1]nonan-3-yl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(2-oxo-1,2-dihydropyridin-3-yl)quinoxalin-2(1H)-one | 1555930-74-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 1-((1R,3R,5S)-8-((1R,3r,5S)-bicyclo[3.3.1]nonan-3-yl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(2-oxo-1,2-dihydropyridin-3-yl)quinoxalin-2(1H)-one
• CAS: 1555930-74-9
• 化学式: C₂₉H₃₄N₄O₂
• 分子量: 470.615
• InChiKey: WXBZKJGJRJVMRX-FGGOGHJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.89
• 重原子数：
  35.0
• 可旋转键数：
  3.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  70.99
• 氢给体数：
  1.0
• 氢受体数：
  5.0

文献信息

• CYCLIC UREA- OR LACTAM-SUBSTITUTED QUINOXALINE-TYPE PIPERIDINE COMPOUNDS AND THE USES THEREOF
  申请人：Purdue Pharma LP

  公开号：EP2880033B1

  公开（公告）日：2020-06-17
• CYCLIC UREA- OR LACTAM-SUBSTITUTED QUINOXALINE-TYPE PIPERIDINE COMPOUNDS AND USES THEREOF
  申请人：Shionogi & Co., Ltd.

  公开号：US20140045830A1

  公开（公告）日：2014-02-13

  The disclosure relates to Cyclic Urea- or Lactam-Substituted Quinoxaline-Type Piperidine Compounds of Formula (I): and pharmaceutically acceptable derivatives thereof wherein R 1 , R 2 , Q a , Y 1 , Z, A, B, Q x , E, G, J, M, U, W, and a are as defined herein, compositions comprising an effective amount of a Cyclic Urea- or Lactam-Substituted Quinoxaline-Type Piperidine Compound, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Cyclic Urea- or Lactam-Substituted Quinoxaline-Type Piperidine Compound.
• US9085561B2
  申请人：——

  公开号：US9085561B2

  公开（公告）日：2015-07-21