Pyrimido<4,5-d>pyrimidin-2,4,5,7-tetron | 26212-10-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 英文名称: Pyrimido<4,5-d>pyrimidin-2,4,5,7-tetron
• 英文别名: 1H,8H-pyrimido[4,5-d]pyrimidine-2,4,5,7-tetraone；1,8-Dihydro-pyrimido[5,6-e]pyrimidine-2,4,5,7-tetrone；1,8-dihydropyrimido[4,5-d]pyrimidine-2,4,5,7-tetrone
• CAS: 26212-10-2
• 化学式: C₆H₄N₄O₄
• 分子量: 196.122
• InChiKey: MTJMLRWKZDLAHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  116
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Universal Base
  申请人：Kataoka Masanori

  公开号：US20100036108A1

  公开（公告）日：2010-02-11

  The present invention provides artificial universal base capable of base pairing nonspecifically with any of four kinds of natural nucleic acid bases (A, T, G, and C) without the function to specifically recognize pairing natural nucleic acid bases for base pair formation. Universal base capable of base paring nonspecifically with four kinds of natural nucleic acid bases, wherein the universal base has a structure represented by the following chemical formula: wherein R represents a monovalent group other than a hydrogen atom.

  本发明提供了一种人工通用碱基，能够非特异性地与四种天然核酸碱基（A、T、G 和 C）中的任何一种进行碱基配对，而无需特异性识别配对天然核酸碱基以进行碱基配对形成。具有非特异性地与四种天然核酸碱基进行碱基配对的通用碱基，其中通用碱基具有以下化学式所代表的结构：其中 R 代表除氢原子以外的一价基团。
• ENZYMATIC SYNTHESIS OF NUCLEIC ACID SEQUENCES
  申请人：Thermo Fisher Scientific Geneart GmbH

  公开号：US20180195099A1

  公开（公告）日：2018-07-12

  The disclosure generally relates to compositions and methods for the enzymatic synthesis of nucleic acid sequences. In particular embodiments 3′ protected nucleotides are used in conjunction with a universal template to direct synthesis.
• US8211899B2
  申请人：——

  公开号：US8211899B2

  公开（公告）日：2012-07-03
• [EN] UNIVERSAL BASE-CONTAINING POLYMER<br/>[FR] POLYMÈRE CONTENANT UNE BASE UNIVERSELLE
  申请人：KEK HIGH ENERGY ACCELERATOR

  公开号：WO2007026595A1

  公开（公告）日：2007-03-08

  [EN] [PROBLEMS] To provide a polymer which forms a base pair nonspecifically with a DNA or an oligonucleotide consisting of a natural nucleic acid base. [MEANS FOR SOLVING PROBLEMS] By conducting polymerization with the use of a universal base based on pyrimido[4,5-d]pyrimidin-2,4,5,7-tetraone, which has been confirmed by the inventors as being capable of forming a base pair with any one of four natural nucleic acid bases, a universal base-containing polymer is synthesized. It is confirmed that this universal base-containing polymer forms a complex with a natural type oligonucleotide.
  [FR] Le problème à résoudre dans le cadre de la présente invention consiste à fournir un polymère qui forme une paire de base de manière non-spécifique avec un ADN ou un oligonucléotide constitué d'une base d'acides nucléiques naturels. La solution proposée consiste à synthétiser un polymère contenant une base universelle en effectuant une polymérisation à l'aide d'une base universelle basée sur la pyrimido[4,5-d]pyrimidin-2,4,5,7-tétraone, les inventeurs ayant confirmé son aptitude à former une paire de base avec n'importe laquelle de quatre bases d'acides nucléiques naturels. Il est confirmé que ce polymère contenant une base universelle forme un complexe avec un oligonucléotide de type naturel.