(5R)-5-(azidomethyl)-3-(4-(4-((1-(3,4-difluorophenyl)-2-methyl-5-o-tolyl-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)oxazolidin-2-one | 1445874-34-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (5R)-5-(azidomethyl)-3-(4-(4-((1-(3,4-difluorophenyl)-2-methyl-5-o-tolyl-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)oxazolidin-2-one
• CAS: 1445874-34-9
• 化学式: C₃₃H₃₂F₃N₇O₂
• 分子量: 615.658
• InChiKey: MKRQIMKYQQKRNP-SANMLTNESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.14
• 重原子数：
  45.0
• 可旋转键数：
  8.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  89.71
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  (5R)-5-(azidomethyl)-3-(4-(4-((1-(3,4-difluorophenyl)-2-methyl-5-o-tolyl-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)oxazolidin-2-one 、 5-乙炔基-1-甲基-1H-咪唑 在 copper(II) sulfate 、 sodium ascorbate 作用下， 以 水 、 叔丁醇 为溶剂， 反应 4.0h， 以74%的产率得到(5R)-3-(4-(4-((1-(3,4-difluorophenyl)-2-methyl-5-o-tolyl-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)-5-((4-(1-methyl-1H-imidazol-5-yl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one
  参考文献：
  名称：

  Anti-tubercular agents. Part 7: A new class of diarylpyrrole–oxazolidinone conjugates as antimycobacterial agents

  摘要：

  In an effort to discover new anti-tubercular agents, a series of new diarylpyrrole oxazolidinone conjugates have been designed and synthesized. The anti-tubercular activity of these new conjugates (4a-n and 5a-d) against Mycobacterium tuberculosis H(37)Rv and drug resistance strains such as M. tuberculosis Rif(R) and M. tuberculosis XDR are discussed, wherein compound 4i has been found to be the most potent amongst the series. MTT assay was performed on the active conjugates of the series (4b-f, 4i and 5c) against mouse macrophage (J-774) cells to evaluate cytotoxic effects and selective index values. In addition, these conjugates (4a-n and 5a-d) are also tested against a panel of Gram-positive and Gram-negative bacterial strains. The docking studies have been carried out to provide some insight into the mechanism of action for this class of compounds. (C) 2013 Published by Elsevier Masson SAS.

  DOI：

  10.1016/j.ejmech.2013.03.027
• 作为产物：
  描述：

  1-(2-甲基苯基)-1,4-戊二酮 在 溶剂黄146 、 gadolinium(III) trifluoromethanesulfonate 作用下， 以 水 、 乙腈 为溶剂， 反应 6.5h， 生成 (5R)-5-(azidomethyl)-3-(4-(4-((1-(3,4-difluorophenyl)-2-methyl-5-o-tolyl-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)oxazolidin-2-one
  参考文献：
  名称：

  Anti-tubercular agents. Part 7: A new class of diarylpyrrole–oxazolidinone conjugates as antimycobacterial agents

  摘要：

  In an effort to discover new anti-tubercular agents, a series of new diarylpyrrole oxazolidinone conjugates have been designed and synthesized. The anti-tubercular activity of these new conjugates (4a-n and 5a-d) against Mycobacterium tuberculosis H(37)Rv and drug resistance strains such as M. tuberculosis Rif(R) and M. tuberculosis XDR are discussed, wherein compound 4i has been found to be the most potent amongst the series. MTT assay was performed on the active conjugates of the series (4b-f, 4i and 5c) against mouse macrophage (J-774) cells to evaluate cytotoxic effects and selective index values. In addition, these conjugates (4a-n and 5a-d) are also tested against a panel of Gram-positive and Gram-negative bacterial strains. The docking studies have been carried out to provide some insight into the mechanism of action for this class of compounds. (C) 2013 Published by Elsevier Masson SAS.

  DOI：

  10.1016/j.ejmech.2013.03.027