3-(2-methoxyphenyl)-2-phenylquinazolin-4(3H)-one | 37856-18-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-(2-methoxyphenyl)-2-phenylquinazolin-4(3H)-one
• 英文别名: 3-(2-methoxy-phenyl)-2-phenyl-3H-quinazolin-4-one；3-(2-Methoxy-phenyl)-2-phenyl-3H-chinazolin-4-on；3-(2-Methoxy-phenyl)-2-phenyl-3H-quinazolin-4-one；3-(2-methoxyphenyl)-2-phenylquinazolin-4-one
• CAS: 37856-18-1
• 化学式: C₂₁H₁₆N₂O₂
• 分子量: 328.37
• InChiKey: SUQHPFPBDKEICZ-UHFFFAOYSA-N

物化性质

• 溶解度：
  >49.3 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  41.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-(2-甲氧基苯基)苯甲酰胺 在 sodium dithionite 、 乙醇 、 五氯化磷 作用下， 生成 3-(2-methoxyphenyl)-2-phenylquinazolin-4(3H)-one
  参考文献：
  名称：

  Familial Aggregation of 7-Year Changes in Musculoskeletal Fitness

  摘要：

  The purpose of this study was to determine the degree of familial resemblance in baseline and 7-year changes in musculoskeletal fitness. Data front the 1981 Canada Fitness Survey and the Campbell's Survey 7-year follow-up were used. The sample consisted of 1264 people (635 males and 629 females) between the ages of 7 and 69 years for whom measurements of musculoskeletal fitness were available at baseline. A subsample of 834 people had measurements at both baseline and 7-year follow-up. Sit-and-reach trunk flexibility, number of push-ups without time limit, number of sit-ups in 60 seconds, and hand-grip strength were used as indicators of musculoskeletal fitness. The data were adjusted for the effects of age and body mass index (and baseline level of the variable for changes) by using regression procedures, and they were standardized to zero mean and unit variance within each of the four sex-by-generation groups (fathers, mothers, sons, and daughters), Familial correlation models were fitted to the data by using the computer software SEGPATH. The results indicate significant familial resemblance for all indicators of musculoskeletal fitness for baseline measures and 7-year changes. The heritabilities, or the percentages of the total variance attributable to heredity, were 64% for trunk flexibility, 37% for push-ups, 59% for sit-ups, and 48% for grip strength. Similarly, heritabilities for the change scores were 48% for trunk flexibility, 52% for push-ups, 41% for sit-ups, and 32% for grip strength. The results suggest that familial, and perhaps genetic, factors are important in explaining the variance in musculoskeletal fitness not only cross-sectionally but also for changes over time.

  DOI：

  10.1093/gerona/56.12.b497

文献信息

• α-Keto Acids as Triggers and Partners for the Synthesis of Quinazolinones, Quinoxalinones, Benzooxazinones, and Benzothiazoles in Water
  作者：Jian Huang、Wei Chen、Jiazhi Liang、Qin Yang、Yan Fan、Mu-Wang Chen、Yiyuan Peng

  DOI：10.1021/acs.joc.1c01497

  日期：2021.11.5

  the synthesis of quinazolinones, quinoxalinones, benzooxazinones, and benzothiazoles from the reactions of α-keto acids with 2-aminobenzamides, benzene-1,2-diamines, 2-aminophenols, and 2-aminobenzenethiols, respectively, is described. The reactions were conducted under catalyst-free conditions, using water as the sole solvent with no additive required, and successfully applied to the synthesis of sildenafil

  由 α-酮酸分别与 2-氨基苯甲酰胺、苯-1,2-二胺、2-氨基苯酚和 2-氨基苯硫醇反应合成喹唑啉酮、喹喔啉酮、苯并恶嗪酮和苯并噻唑的通用有效方法是描述。该反应在无催化剂条件下进行，以水为唯一溶剂，无需任何添加剂，成功应用于西地那非的合成。更重要的是，这些反应可以大规模进行，产物可以很容易地通过过滤和乙醇洗涤（或结晶）进行纯化。
• Familial Aggregation of 7-Year Changes in Musculoskeletal Fitness
  作者：P. T. Katzmarzyk、N. Gledhill、L. Perusse、C. Bouchard

  DOI：10.1093/gerona/56.12.b497

  日期：2001.12.1

  The purpose of this study was to determine the degree of familial resemblance in baseline and 7-year changes in musculoskeletal fitness. Data front the 1981 Canada Fitness Survey and the Campbell's Survey 7-year follow-up were used. The sample consisted of 1264 people (635 males and 629 females) between the ages of 7 and 69 years for whom measurements of musculoskeletal fitness were available at baseline. A subsample of 834 people had measurements at both baseline and 7-year follow-up. Sit-and-reach trunk flexibility, number of push-ups without time limit, number of sit-ups in 60 seconds, and hand-grip strength were used as indicators of musculoskeletal fitness. The data were adjusted for the effects of age and body mass index (and baseline level of the variable for changes) by using regression procedures, and they were standardized to zero mean and unit variance within each of the four sex-by-generation groups (fathers, mothers, sons, and daughters), Familial correlation models were fitted to the data by using the computer software SEGPATH. The results indicate significant familial resemblance for all indicators of musculoskeletal fitness for baseline measures and 7-year changes. The heritabilities, or the percentages of the total variance attributable to heredity, were 64% for trunk flexibility, 37% for push-ups, 59% for sit-ups, and 48% for grip strength. Similarly, heritabilities for the change scores were 48% for trunk flexibility, 52% for push-ups, 41% for sit-ups, and 32% for grip strength. The results suggest that familial, and perhaps genetic, factors are important in explaining the variance in musculoskeletal fitness not only cross-sectionally but also for changes over time.