甲基2-乙基-1,3-苯并噻唑-5-羧酸酯 | 32783-60-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 中文名称: 甲基2-乙基-1,3-苯并噻唑-5-羧酸酯
• 英文名称: 2-Ethyl-benzothiazole-5-carboxylic acid methyl ester
• 英文别名: Methyl 2-ethylbenzo[d]thiazole-5-carboxylate；methyl 2-ethyl-1,3-benzothiazole-5-carboxylate
• CAS: 32783-60-1
• 化学式: C₁₁H₁₁NO₂S
• 分子量: 221.28
• InChiKey: ZMHVCSROHAOEMG-UHFFFAOYSA-N

物化性质

• 沸点：
  330.9±15.0 °C(Predicted)
• 密度：
  1.250±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  67.4
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2934999090

文献信息

• USE OF ANTIRESORPTIVE COMPOUNDS TO PREVENT IONIZING RADIATION-INDUCED ACTIVATION OF OSTEOCLASTS AND RESULTING BONE LOSS
  申请人：Bateman Ted A.

  公开号：US20100068211A1

  公开（公告）日：2010-03-18

  A method of preventing or treating ionizing radiation-associated loss of bone mass, bone density or bone strength in a subject is provided, comprising administering to the subject an amount of an antiresorptive or osteoclast inhibiting compound sufficient to prevent or mitigate loss of bone mass, density or strength. A method of preventing or treating radiation-associated increase in the number or activity of osteoclasts in a subject is also provided, comprising administering to the subject an amount of an antiresorptive compound sufficient to reduce osteoclast numbers or reduce osteoclast activity and prevent resulting loss of bone mass, density or strength.