1-(4-isopropyl-pyrid-2-yl)-cyclopropylamine | 943925-69-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-(4-isopropyl-pyrid-2-yl)-cyclopropylamine
• 英文别名: 1-(4-isopropyl-pyridin-2-yl)-cyclopropylamine；1-(4-Isopropylpyridin-2-yl)cyclopropanamine；1-(4-propan-2-ylpyridin-2-yl)cyclopropan-1-amine
• CAS: 943925-69-7
• 化学式: C₁₁H₁₆N₂
• 分子量: 176.261
• InChiKey: RPYKMZGMPZPSNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• MACROCYCLIC COMPOUNDS USEFUL AS BASE INHIBITORS
  申请人：Betschart Claudia

  公开号：US20090029960A1

  公开（公告）日：2009-01-29

  The invention relates to novel macrocyclic compounds of the formula in which all of the variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.

  该发明涉及一种新型的大环化合物，其公式如下，在自由碱基形式或酸盐形式下，其中所有变量如规范中所定义，其制备方法，用作药物的方法以及包含它们的药物。
• MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS
  申请人：Laumen Kurt

  公开号：US20090312370A1

  公开（公告）日：2009-12-17

  The invention relates to novel macrocyclic compounds of the formula in which all of the variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.

  本发明涉及新的大环化合物，其化学式为，在该化学式中，所有变量均如规范所定义，以自由碱基形式或酸加成盐形式存在，涉及它们的制备方法，它们作为药物的用途以及包含它们的药物。
• US8039455B2
  申请人：——

  公开号：US8039455B2

  公开（公告）日：2011-10-18
• [EN] MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS<br/>[FR] COMPOSES MACROCYCLIQUES UTILISES COMME INHIBITEURS DE BACE
  申请人：NOVARTIS AG

  公开号：WO2007077004A1

  公开（公告）日：2007-07-12

  [EN] The invention relates to novel macrocyclic compounds of the formula (I), in which all of the variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
  [FR] L'invention concerne de nouveaux composés macrocycliques de formule (I), dans laquelle toutes les variables sont telles que définies dans la spécification, dans une forme de base libre ou dans une forme saline d'addition acide, leur préparation, leur utilisation en tant que médicaments et des médicaments les renfermant.
• [EN] MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS<br/>[FR] COMPOSÉS MACROCYCLIQUES UTILES COMME INHIBITEURS DE LA BACE
  申请人：NOVARTIS AG

  公开号：WO2008009750A2

  公开（公告）日：2008-01-24

  [EN] The invention relates to novel macrocyclic compounds of the Formula (I) in which all of the variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
  [FR] L'invention concerne de nouveaux composés macrocycliques représentés par la Formule (I) dans laquelle toutes les variables sont telles que définies dans la description, sous forme de base libre ou sous une forme de sel d'addition avec un acide ; elle concerne également la préparation de ces composés, leur utilisation comme médicaments et les médicaments les comprenant.