1H,2H,3H-pyrido[1,2-c]pyrimidine-1,3-dione | 118768-08-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 英文名称: 1H,2H,3H-pyrido[1,2-c]pyrimidine-1,3-dione
• 英文别名: pyrido[1,2-c]pyrimidine-1,3-dione
• CAS: 118768-08-4
• 化学式: C₈H₆N₂O₂
• 分子量: 162.15
• InChiKey: NMVFPAXKGOERKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• SUBSTITUTED TETRAHYDROCARBAZOLE AND CARBAZOLE CARBOXAMIDE COMPOUNDS
  申请人：Bristol-Myers Squibb Company

  公开号：US20140378475A1

  公开（公告）日：2014-12-25

  Disclosed are compounds of Formula (I) wherein: the two dotted lines represent either two single or two double bonds; Q is: R 1 is F, Cl, —CN, or —CH 3 ; R 2 is Cl or —CH 3 ; R 3 is —C(CH 3 ) 2 OH or —CH 2 CH 2 OH; R a is H or —CH 3 ; each R b is independently F, Cl, —CH 3 , and/or —OCH 3 ; and n is zero, 1, or 2. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

  公开的是Formula (I)的化合物，其中：两条虚线代表两个单键或两个双键；Q是：R1是F、Cl、—CN或—CH3；R2是Cl或— ；R3是—C( )2OH或—CH2CH2OH；Ra是H或— ；每个Rb独立地是F、Cl、— 和/或—O ；n为零、1或2。还公开了将这些化合物用作Bruton酪氨酸激酶（Btk）抑制剂的方法，以及包含这些化合物的药物组合物。这些化合物在治疗、预防或减缓多种治疗领域的疾病或疾病的进展方面非常有用，如自身免疫疾病和血管疾病。
• [EN] CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS<br/>[FR] COMPOSÉS DE CARBAZOLE-CARBOXAMIDE UTILES COMME INHIBITEURS DE KINASES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2014210087A1

  公开（公告）日：2014-12-31

  Disclosed are compounds of Formula (I); and salts thereof, wherein:Formula (II); Q is: R1 is -C(CH3)2OH, -NHC(=0)C(CH3)3, -N(CH3)2, or -CH2Rd; R2 is CI or -CH3; R3 is H, F, or -CH3; Ra is H or -CH3; Rb is H, F, CI, or -OCH3 Rc is H or F; and Rd is -OH, -OCH3, -NHC(=0)CH3, or fORMULA (III), Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

  公开了Formula (I)的化合物及其盐，其中：Formula (II)；Q是：R1为-C(CH3)2OH，-NHC(=0)C( )3，-N( )2，或-CH2Rd；R2为CI或- ；R3为H，F或- ；Ra为H或- ；Rb为H，F，CI或-O ；Rc为H或F；Rd为-OH，-O ，-NHC(=0) ，或Formula (III)。还公开了使用这些化合物作为Bruton酪氨酸激酶（Btk）抑制剂的方法，以及包含这些化合物的药物组合物。这些化合物在治疗、预防或减缓各种治疗领域的疾病或障碍方面具有用途，如自身免疫疾病和血管疾病。
• SUBSTITUTED TETRAHYDROCARBAZOLE AND CARBAZOLES CARBOXAMIDE COMPOUNDS
  申请人：Bristol-Myers Squibb Company

  公开号：US20160194338A1

  公开（公告）日：2016-07-07

  Disclosed are compounds of Formula (I) wherein: the two dotted lines represent either two single or two double bonds; Q is: R 1 is F, Cl, —CN, or —CH 3 ; R 2 is C 1 or —CH 3 ; R 3 is —C(CH 3 ) 2 OH or —CH 2 CH 2 OH; R a is H or —CH 3 ; each R b is independently F, Cl, —CH 3 , and/or —OCH 3 ; and n is zero, 1, or 2. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

  本发明涉及式（I）的化合物，其中：两个点状线代表两个单键或两个双键；Q为：R1为F、Cl、—CN或—CH3；R2为C1或— ；R3为—C( )2OH或—CH2CH2OH；Ra为H或— ；每个Rb独立地为F、Cl、— 和/或—O ；n为零、1或2。本发明还涉及使用这些化合物作为布鲁顿酪氨酸激酶（Btk）抑制剂的方法，以及包含这些化合物的制药组合物。这些化合物在治疗、预防或减缓多种治疗领域的疾病或疾病进展方面是有用的，例如自身免疫性疾病和血管疾病。
• CARBAZOLE CARBOXAMIDE COMPOUNDS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20160200710A1

  公开（公告）日：2016-07-14

  Disclosed are compounds of Formula (I); and salts thereof, wherein: Formula (II); Q is: R 1 is —C(CH 3 )2OH, —NHC(=0)C(CH 3 ) 3 , —N(CH3)2, or —CH 2 R d ; R 2 is CI or —CH 3 ; R 3 is H, F, or —CH 3 ; R a is H or —CH 3 ; R b is H, F, CI, or —OCH3 R c is H or F; and Rd is —OH, —OCH3, —NHC(=0)CH3, or fORMULA (III), Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

  本发明涉及式（I）化合物及其盐，其中：式（II）；Q为：R1为—C（CH3）2OH，—NHC（=0）C（ ）3，—N（ ）2或—CH2Rd；R2为CI或— ；R3为H，F或— ；Ra为H或— ；Rb为H，F，CI或—O ；Rc为H或F；Rd为—OH，—O ，—NHC（=0） 或式（III），还公开了使用这些化合物作为Bruton酪氨酸激酶（Btk）抑制剂的方法以及包含这些化合物的制药组合物。这些化合物在多种治疗领域中，如自身免疫疾病和血管疾病中，用于治疗、预防或减缓疾病或疾病的进展。
• Substituted tetrahydrocarbazole and carbazole carboxamide compounds
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US10106559B2

  公开（公告）日：2018-10-23

  Disclosed are compounds of Formula (I) wherein: the two dotted lines represent either two single or two double bonds; Q is: R1 is F, Cl, —CN, or —CH3; R2 is Cl or —CH3; R3 is —C(CH3)2OH or —CH2CH2OH; Ra is H or —CH3; each Rb is independently F, Cl, —CH3, and/or —OCH3; and n is zero, 1, or 2. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

  公开了式 (I) 的化合物 其中：两条虚线代表两个单键或两个双键；Q 是 R1是F、Cl、-CN或-CH3；R2是Cl或- ；R3是-C( )2OH或-CH2CH2OH；Ra是H或- ；每个Rb独立地是F、Cl、- 和/或-O ；以及n是零、1或2。还公开了使用此类化合物作为布鲁顿酪氨酸激酶（Btk）抑制剂的方法，以及包含此类化合物的药物组合物。这些化合物可用于治疗、预防或减缓各种治疗领域的疾病或紊乱，如自身免疫性疾病和血管疾病。